Steroid Dependent Nephrotic Syndrome

What is Steroid Dependent Nephrotic Syndrome?

Steroid Dependent Nephrotic Syndrome (SDNS) is a condition where excessive amounts of protein are lost in the urine, and can result in swelling in the body as the excess amount of protein spills into the body. It is a form of nephrotic syndrome, in which damage to the glomeruli in the kidneys makes them unable to properly filter the protein from the blood. This can lead to a range of serious complications, such as fluid buildup in the lungs, electrolyte imbalances, and kidney failure.

SDNS is often the result of an underlying condition such as diabetes, lupus, or systemic vasculitis. It can also be caused by certain medications, or from an unknown cause. The diagnosis is made through a combination of laboratory tests, physical examination, and imaging studies.


The goal of treatment for SDNS is to reduce the proteinuria, reduce the swelling in the body, and prevent complications. Treatment typically begins with corticosteroid drugs, such as prednisone or prednisolone. This is often successful in reducing symptoms and helping to prevent further damage to the kidneys.

In cases where corticosteroids are not effective, other medications may be tried. These can include ACE inhibitors, ACE-2 inhibitors, immunosuppressants, or biologics. In cases that are resistant to medical therapy, a technique called hemofiltration may be used.

Prevention & Outlook

There is no way to prevent SDNS from occurring, however it can be managed with early diagnosis and effective treatment. In many cases, the condition can be managed with medication, and the patient can have a relatively normal life. However, some patients may require dialysis or a kidney transplant in more advanced stages of the disease.

It is important to remember that SDNS is a serious condition, and it is important to get an early diagnosis and begin treatment as soon as possible.

Suport groups

If you or a loved one has been diagnosed with SDNS, support groups can be a great help in providing moral and emotional support during this difficult time. There are several online groups and organizations that provide information and resources for people with SDNS. Some of these include:

  • American Kidney Fund
  • NephCure Kidney International
  • National Kidney Foundation
  • Lupus Research Alliance
  • Kidney Community Support