Relapsed platinum-sensitive Ovarian cancer


Relapsed Platinum-Sensitive Ovarian Cancer

Relapsed platinum-sensitive ovarian cancer is a type of cancer that has come back after a period of response to treatment with platinum-based drugs, such as cisplatin or carboplatin. It is estimated that around 45-50% of women with ovarian cancer will experience a recurrence of their disease.

When the disease relapses, it is typically treated with the same platinum-based chemotherapy drugs, but at a higher dose than was used before. In some cases, chemotherapy may be combined with targeted therapies, such as monoclonal antibodies (drugs that target a specific cancer molecule), immunotherapies (drugs that boost the immune system) or vaccine therapies (drugs that stimulate the body’s own defenses). Surgical resection may also be used if the patient’s cancer has spread to other organs.

Relapsed ovarian cancer can be very difficult to treat and can require many different approaches. Unfortunately, the outlook for patients with this type of cancer is not very good, as most have a limited life expectancy.


The symptoms of relapsed ovarian cancer depend on where the cancer is located and how far it has spread. The most common symptoms include:

  • Tiredness or fatigue
  • Weight loss
  • Abdominal pain or swelling
  • Bloating or fullness
  • Loss of appetite
  • Nausea and vomiting
  • Changes in bowel movements
  • Frequent urination
  • Pelvic pain or cramping

These symptoms can be caused by relapsed ovarian cancer or other, less serious conditions. It is important to see a doctor if any of these symptoms last for more than two weeks.


Relapsed ovarian cancer can be difficult to diagnose, as some of the symptoms can be vague and non-specific. If your doctor suspects that you have relapsed ovarian cancer, they will likely order a series of diagnostic tests, including:

  • Blood tests to look for elevated levels of CA-125, a protein associated with ovarian cancer
  • Ultrasound to detect any tumors in the abdominal area
  • CT scans or MRI to look for signs of cancer spread
  • Laparoscopy to examine the abdominal area
  • Biopsy to confirm the diagnosis


Treatment for relapsed ovarian cancer depends on the type of cancer, the severity of the disease, and the patient’s overall health. Treatment plans may include:

  • Surgery to remove tumors or affected organs, if necessary
  • Chemotherapy using high doses of platinum-based drugs
  • Targeted therapies, such as monoclonal antibodies or immunotherapies
  • Radiation therapy to kill cancer cells
  • Clinical trials for access to new drugs

The goal of treatment is to keep the disease under control for as long as possible and to maintain good quality of life. However, most patients with relapsed ovarian cancer have a limited life expectancy.