T-Cell Prolymphocytic Leukemia

What is T-Cell Prolymphocytic Leukemia?

T-Cell Prolymphocytic Leukemia (T-PLL) is a rare form of leukemia that affects B-cells which are a type of white blood cell. The condition is characterized by an overproduction of immature T cells that are unable to mature properly. These abnormal T cells accumulate in the bone marrow, lymph nodes, and blood, resulting in symptoms such as fatigue, weight loss, night sweats, and recurrent infections.

Signs and Symptoms

The signs and symptoms associated with T-PLL can vary depending on the severity of the disease. Common symptoms include:

  • Fatigue
  • Weight loss
  • Night sweats
  • Fever
  • Recurrent infections
  • Enlarged lymph nodes or spleen

Diagnosis and Treatment

T-PLL is typically diagnosed through physical exam, blood tests, and a bone marrow biopsy. A bone marrow biopsy involves taking a sample of the marrow and sending it to a laboratory for analysis. The sample is then examined on a microscopic level to determine if the signs of T-PLL are present.

Treatments for T-PLL often depend on the severity of the disease and the individual patient’s overall health. Common treatments include chemotherapy, radiation therapy, and/or stem cell transplants. In some cases, doctors may use novel combination therapies to improve the effectiveness of the treatment.


The prognosis for T-PLL depends on the individual. Treatment is typically palliative, with the goal of relieving symptoms and improving quality of life. In some cases, the disease can be treated with curative intent. However, this is not the norm and the survival rate is generally quite low.