High-grade B-cell Lymphoma (HGBCL)

High-grade B-cell Lymphoma (HGBCL)

High-Grade B-cell lymphoma (HGBCL) is an aggressive form of non-Hodgkin's lymphoma, a type of cancer that begins in cells of the immune system. The disease is divided into two primary types: diffuse large B-cell lymphoma (DLBCL) and Burkitt Lymphoma. Approximately 85% of non-Hodgkin's lymphomas are of this high-grade type.

HGBCL is the most common adult lymphoma, affecting more than 50,000 people each year in the United States. It is a fast-growing cancer that rapidly reaches high levels in the body. In many cases, it can cause a build-up of tumor cells in areas such as the abdomen, chest, neck, and groin.

Early symptoms of HGBCL can include painless swollen lymph nodes in the neck, underarms, or groin. Other symptoms may include fever, night sweats, weight loss, fatigue, and an overall feeling of discomfort. If these signs and symptoms are present, it is important for a patient to seek medical attention immediately.

Diagnosis of HGBCL is typically made through a biopsy of the affected cells. Imaging tests such as x-rays and CT scans can also be used to detect areas of enlargement within the body. Further blood tests may be run to look for elevated levels of certain white blood cell markers.

Treatment for HGBCL depends on the stage of the cancer, the patient’s overall health, and the extent of the disease. Common treatments include chemotherapy, radiation therapy, immunotherapy, several types of targeted therapy, and stem cell transplant. Surgery may also be used to remove a tumor or involved lymph nodes.

Prognosis for HGBCL is generally good if the cancer is caught and treated early. If the cancer has spread to other organs or tissues, it becomes more difficult to treat and the prognosis may be poor. An individual’s prognosis will depend on many factors such as the type of lymphoma, the stage of the cancer, and the patient’s overall health.

It is important for those at risk of lymphoma, or those with early symptoms, to discuss these concerns with their doctor. Early diagnosis and treatment of HGBCL are key to achieving the highest chances of remission.