Factor II deficiency

What is Factor II Deficiency?

Factor II deficiency, also known as prothrombin deficiency, is an inherited coagulation disorder. It is caused by a deficiency in an important clotting factor known as prothrombin. Prothrombin is a plasma protein that works with other clotting factors, known as Factors I, V, VII and X, to form clots and stop bleeding. When someone is deficient in prothrombin, it can result in prolonged or excessive bleeding.

Symptoms of Factor II Deficiency

The symptoms of Factor II deficiency can vary from person to person, but there are some common signs and symptoms to watch for. Symptoms may include:

  • Easy or excessive bruising
  • Prolonged or excessive bleeding from cuts or wounds
  • Nosebleeds
  • Bleeding from the gums
  • Menstrual irregularities
  • Frequent episodes of blood in the urine or stool
  • Abnormal bleeding after surgery, dental work or childbirth

Diagnosing Factor II Deficiency

If you have any of the above symptoms, it is important to speak with your doctor, as they may suggest tests to diagnose Factor II deficiency. These tests typically involve a blood sample, which is used to measure the levels of prothrombin as well as the other clotting factors. If a physician suspects a Factor II deficiency, they may also suggest genetic testing to verify the diagnosis or identify mutations in the gene responsible for producing prothrombin.

Treatments for Factor II Deficiency

Fortunately, there are treatments available to help manage the symptoms of Factor II deficiency. Depending on the severity of a person’s symptoms, treatment may involve the use of clotting factor concentrates or replacement therapy, Vitamins K and C supplementation, or antifibrinolytic agents. In some severe cases, surgery may be necessary to close a wound or stop bleeding.


Factor II deficiency is a rare but serious coagulation disorder that can cause excessive bleeding and other health complications. It is important to speak with your doctor if you are experiencing any of the above symptoms, as early diagnosis and treatment can greatly reduce the risk of further complications.