Apolipoprotein CII

What is Apolipoprotein CII?

Apolipoprotein C-II (ApoC-II), also known as ApoC-2, is a protein that helps make triglycerides in the body. Triglycerides are the building blocks of fat in the body and are necessary for many bodily functions. ApoC-II is an essential component of very low-density lipoproteins (VLDL), which carry fat from the liver to other parts of the body.

Types of Apolipoprotein CII

There are two forms of ApoC-II: ApoC-II(A) and ApoC-II(B). ApoC-II(A) is produced in the liver and is the more active form of ApoC-II; it helps move fat out of the liver and into other parts of the body. ApoC-II(B) is produced in the intestine and is less active; it helps move fat out of the intestine and into the bloodstream.


ApoC-II is prepared using CRISPR/Cas9 technology or other molecular cloning techniques. This process results in the production of recombinant ApoC-II, which is modified to be more active than the natural form of the protein. In addition, synthetic analogues of ApoC-II have been developed that mimic the function of the natural protein.


ApoC-II is administered through injection or inhalation, depending on the method of delivery. Injection is the most common method for administering ApoC-II. The injection may be intramuscular, intravenous, or subcutaneous. Inhalation is the preferred method of administering ApoC-II to those with respiratory conditions, such as asthma.


The use of ApoC-II is associated with a number of potential risks, including allergic reactions, infection, and an increased risk of developing blood clots or stroke. It is also possible to develop an allergy to the protein itself, which can cause difficulty breathing, hives, swelling, and rash. In addition, ApoC-II can interact with certain medications, so it is important to discuss any current medications with a healthcare provider before using ApoC-II.

Why use Apolipoprotein CII?

ApoC-II is used to treat and manage various disorders, including lipid disorders, metabolic syndrome, and atherosclerosis. It is also used to reduce cholesterol levels and triglyceride levels. Additionally, ApoC-II has been studied for its potential ability to treat inflammatory conditions and obesity.

When to use Apolipoprotein CII?

ApoC-II should be used as directed by a healthcare provider. It should be taken as directed, even if there are no symptoms present, as ApoC-II can help prevent future health issues. If symptoms do occur, contact a healthcare provider immediately.