Refractory Ewing Sarcoma

Refractory Ewing Sarcoma: A Rare Form of Cancer Affecting Children and Young Adults

Ewing sarcoma is a rare, aggressive type of cancer that occurs in bones, bone marrow, and soft tissue. Children and young adults are the most commonly affected, with only five to ten percent of diagnoses occurring in adults over the age of 30. Refractory Ewing sarcoma is the term used to describe cases where the cancer is unresponsive or resistant to traditional treatments, such as chemotherapy and radiation. Unfortunately, refractory Ewing sarcoma carries a poor prognosis, and it is essential for patients to explore all current and emerging treatments to gain the best chance of survival.

The Symptoms of Refractory Ewing Sarcoma

Refractory Ewing sarcoma often presents itself with symptoms that are similar to other bone conditions, such as bone pain, limping, joint stiffness, swelling, tenderness, or a visible mass. While pain may be the most common symptom, pain alone does not indicate the presence of cancer and other medical conditions must be ruled out before receiving a diagnosis. If you or your child is experiencing any of these symptoms, it is essential to see your doctor immediately for further testing.

Diagnosing Refractory Ewing Sarcoma

To diagnose refractory Ewing sarcoma, doctors will typically review patient history and X-ray imagery. They may also request an MRI or CT scan to get a better view of the affected area. Additionally, the patient may need to have a biopsy to confirm the diagnosis and determine the best course of treatment.

Treating Refractory Ewing Sarcoma

Patients with refractory Ewing sarcoma can experience a wide range of treatments depending on the location, size, and stage of the cancer. Traditional treatments such as chemotherapy and radiation may still be an option, however, newer and more advanced treatments such as targeted therapy, immunotherapy, and surgery should also be considered. Patients might also benefit from participation in clinical trials, as they provide access to treatments that are still in development.

Living with Refractory Ewing Sarcoma

Refractory Ewing sarcoma is an aggressive form of cancer that is difficult to treat and require special attention to manage. Patients should work together with their medical team to develop a personalized care plan and make sure that they understand all of their treatment options. Additionally, it is also important for patients to make sure to get plenty of rest, maintain a balanced diet, and participate in regular physical activity to keep their energy levels up.

Support for Refractory Ewing Sarcoma

Having cancer can be difficult, and it is important to know that you are not alone. There are many emotional and physical support resources available for patients with refractory Ewing sarcoma, their families, and their caregivers. These can include support groups, counseling services, and educational programs. Patients may consider connecting with other cancer survivors as well, as many have valuable experience on how to manage the disease.


Refractory Ewing sarcoma is a rare and aggressive form of cancer that is challenging to treat. It is essential for patients to work closely with their medical team to discuss all available treatment options and make sure that they are informed about the disease. Additionally, patients should take the time to find resources that can support them emotionally and physically throughout their cancer journey.