Recurrent Mismatch Repair-deficient (dMMR) Endometrial Cancer

Introduction to Recurrent Mismatch Repair-deficient (dMMR) Endometrial Cancer

Recurrent Mismatch Repair-deficient (dMMR) Endometrial Cancer is a rare type of endometrial cancer that is characterized by defects in the mismatch repair pathway. This type of cancer is associated with an increased risk of recurrence and a poorer prognosis compared to other endometrial cancers. dMMR Endometrial Cancer has a tendency to be more aggressive, spread to other organs, and is more likely to resist chemotherapy and radiation.

Cause of dMMR Endometrial Cancer

The exact cause of dMMR endometrial cancer is not completely understood. It is believed to be caused by a genetic mutation that impairs the function of the mismatch repair (MMR) pathway. The MMR pathway is responsible for repairing errors that occur during DNA replication. When the MMR pathway is impaired, cells can’t repair errors, which can lead to the formation of cancerous cells. dMMR endometrial cancer is most commonly found in post-menopausal women.

Diagnosis of dMMR Endometrial Cancer

dMMR Endometrial Cancer is typically diagnosed with a physical examination, an imaging scan, and a biopsy. Women with a history of endometrial cancer should be tested for the MMR mutation and seek to have it confirmed with a biopsy.

Treatment of dMMR Endometrial Cancer

The treatment for dMMR endometrial cancer is different than that of other endometrial cancers. Treatment options may include:

Surgery - Surgery may be used to remove the cancerous tumor.
Chemotherapy - Certain chemotherapy drugs may be used to try and stop or slow the growth of the cancer.
Radiation Therapy - Radiation may be used in combination with other treatments to shrink or destroy the tumor.
Immunotherapy - Immunotherapy may be used to help the body’s immune system to fight the cancer.

It is important to talk to a medical professional about the best treatment options for an individual’s particular case.

Complications of dMMR Endometrial Cancer

The complications of dMMR Endometrial Cancer can be severe and potentially life-threatening. Possible complications may include:

Spread of the cancer to other parts of the body
Resistance to chemotherapy and radiation
Recurrence of the cancer
Infertility
Organ damage

It is important to be aware of any potential complications and risks associated with treatment.

Conclusion

Recurrent Mismatch Repair-deficient (dMMR) Endometrial Cancer is a rare form of endometrial cancer that is characterized by defects in the MMR pathway and is associated with an increased risk of recurrence and poorer prognosis. It is typically diagnosed with a physical examination, an imaging scan, and a biopsy. Treatment options may include surgery, chemotherapy, radiation therapy, or immunotherapy. Complications of dMMR endometrial cancer can be severe and it is important to talk to a medical professional about the best treatment options for a person’s particular case.