Palmo-Plantar Pustulosis

What Is Palmo-Plantar Pustulosis (PPP)?

Palmo-Plantar Pustulosis (PPP) is a chronic, recurrent inflammatory condition of the palms and the soles characterised by redness, pus-filled blisters, and thick, dry, scaly plaques. It is caused by an abnormal response of the immune system and is considered to be a type of psoriasis, although the exact cause is unknown.

Signs and Symptoms of PPP

The main symptoms of PPP include:

  • Painful blisters or pustules on the palms and/or soles, which may be filled with pus.
  • Redness and swelling of the palms and/or soles.
  • Warmth or burning sensation on the affected area.
  • Itching and tenderness of the affected area.
  • Thick, dry, scaly plaques on the palms and/or soles.

In some cases, PPP can cause joint pain and swelling, as well as fatigue, malaise, and fever.

Diagnosis of PPP

The diagnosis of PPP is usually done by a dermatologist through a physical examination of the affected area. Diagnostic tests such as skin biopsy, laboratory tests, and imaging tests may be done to rule out other conditions and confirm the diagnosis.

Treatment of PPP

The treatment of PPP depends on the severity of the condition. Mild cases may need no treatment, while severe cases may require medications such as topical steroids, immunosuppressants, retinoids, and biologics, as well as phototherapy. Other treatment options include lifestyle modifications, hot or cold compresses, and laser therapy.