NYHA Functional Class II-IV Pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a chronic, progressive, and life-threatening form of high blood pressure that affects the lungs and the right side of the heart. Patients with PAH are classified by the New York Heart Association (NYHA) functional class system, which ranges from class I-IV, with class IV being the most serious.

Patients with NYHA functional class II-IV PAH have more severe symptoms than those with class I and require more aggressive treatment. Symptoms can include shortness of breath, fatigue, chest pain, dizziness, swelling in the legs, and fainting. If left untreated, it can lead to heart failure and in some cases death.

Treating NYHA Functional Class II-IV Pulmonary arterial hypertension

The main goal for treating PAH in patients with NYHA functional class II-IV is to improve exercise capacity and quality of life, and slow disease progression. Treatment often includes a combination of medications and lifestyle changes. Patients should work closely with their healthcare team to create an individualized treatment plan to best manage their condition.

Medications

Endothelin receptor antagonists (ERAs)
Prostanoid drugs
Soluble guanylate cyclase stimulators (sGCs)
Phosphodiesterase-5 inhibitors (PDE-5 inhibitors)
Vasodilators

Lifestyle Changes

Recognizing and avoiding triggers that worsen pulmonary arterial pressure
Exercising regularly according to doctor’s advice
Eating a balanced and healthy diet
Quitting smoking and avoiding second-hand smoke
Practicing relaxation techniques and stress management

Living with NYHA functional class II-IV PAH can be challenging, but with the right care and lifestyle adjustments, it is possible to slow down disease progression and improve quality of life.