CSF coccidioides complement fixation test

What is CSF Coccidioides Complement Fixation Test?

CSF Coccidioides Complement Fixation Test is a laboratory test used to detect the presence of a antibody (antigen-antibody complex) against Coccidioides immitis—the causative agent of coccidioidomycosis—in the cerebrospinal fluid (CSF) of patients suffering from the pertaining condition.

Preparing for the Test

Patients are advised to inform their doctor about all medications they are currently consuming before going through a CSF Coccidioides Complement Fixation Test. Depending on the situation, the doctor may advise the patient to stop taking specific medications for a specified time period prior to the test.

Procedure of the Test

The procedure typically follows this pattern:

  • A sample of CSF is collected from the patient and sent to the laboratory for testing.
  • The sample is then combined with a specific antigen against Coccidioides immitis.
  • The mixture is heated or subjected to other treatments in order to separate any existing antigen-antibody complex.
  • The separated complexes are then tested for the presence of specific antibodies.
  • If present, it can be concluded that the patient is suffering from coccidioidomycosis.
  • Types of CSF Coccidioides Complement Fixation Test

    The CSF Coccidioides Complement Fixation Test has two distinct variants –

  • Rapid antigen assay
  • Turbidity test
  • The rapid antigen assay involves heating the antigen-antibody complex attained from the sample and then testing it for the presence of specific antigens. The turbidity test involves checking for the presence of antigens using a light beam passing through the sample.

    Risks Associated with the Test

    CSF Coccidioides Complement Fixation Test is generally a safe procedure and does not present any major risks. Some potential risks include infection and allergic reactions such as redness, swelling, and itching at the needle insertion site.

    Why is the test Performed?

    The CSF Coccidioides Complement Fixation Test is performed to diagnose coccidioidomycosis in patients, as well as to monitor any recurrence or treatment response of the condition. It is also performed in order to identify possible complications associated with coccidioidomycosis including sometimes fatal meningoencephalitis.

    When is the Test Performed?

    The CSF Coccidioides Complement Fixation Test is usually recommended by doctors when they suspect a patient of suffering from coccidioidomycosis. In cases of confirmed coccidioidomycosis, the test may be conducted periodically to keep track of the patient’s treatment response.