Metastatic Epithelioid Sarcoma

Metastatic Epithelioid Sarcoma

Metastatic Epithelioid Sarcoma is a rare and deadly type of soft tissue cancer that affects the deep soft tissue of the body including the arms and legs. It is more aggressive than other types of sarcomas and is often not treatable. It is a malignant tumor and can be fatal.

Epithelioid Sarcoma generally begins in the lower extremities or the trunk and grows until it spreads to other parts of the body. It can appear as a firm, painless mass, but can also present as an ulcerated wound. Generally, Epithelioid Sarcoma starts off in one area, like an arm or leg, and can easily spread to the lungs, liver, and other parts of the body. As the cancer grows, it can eventually metastasize to the liver, lungs, and other organs.

Though the exact cause of Epithelioid Sarcoma is still unknown, recent research suggests a link between the condition and infections like HPV and EBV. Other potential risk factors include radiation exposure, exposure to certain chemicals, and genetic changes like deletions of certain genes.

Treatment for Epithelioid Sarcoma varies greatly depending on the location and extent of the tumor. Surgery is usually recommended to remove the tumor, while chemotherapy and radiation may be recommended for metastasized tumors.

If not detected early, Epithelioid Sarcoma can spread and become difficult to treat. It is important to consult with your doctor if you have a suspicious lump or area that looks like a tumor.

Symptoms of Metastatic Epithelioid Sarcoma

  • Firm mass
  • Ulcerated wound
  • Pain
  • Fever
  • Swelling
  • Weight loss
  • Fatigue


Diagnosis of Epithelioid Sarcoma is often difficult and involves a variety of tests and procedures.

  • Physical exam
  • Imaging tests such as X-rays, CT scans, and MRI scans
  • Biopsy of the tumor
  • Tissue tests
  • Blood tests to check for tumor markers
  • Genetic testing of a sample of the tumor

Treatment for Metastatic Epithelioid Sarcoma

Treatment for Epithelioid Sarcoma depends on the size, location, and extent of the tumor. Generally, treatment options include:

  • Surgery to remove the tumor, if possible
  • Chemotherapy to kill any remaining cancer cells
  • Radiation therapy, either alone or in combination with chemotherapy, to target cancer cells
  • Targeted therapy to target specific genes in the cancer cells
  • Immunotherapy to help the body's natural defenses fight the cancer cells


The prognosis for patients with Epithelioid Sarcoma depends on the size, stage, and location of the tumor as well as the response to treatment. In general, the prognosis is poor and the cancer can be fatal if not treated promptly.