Low-grade Upper Tract Urothelial Cancer (LG-UTUC)

What is Low-Grade Upper Tract Urothelial Cancer (LG-UTUC)?

Low-grade upper tract urothelial cancer (LG-UTUC) is a rare form of urinary bladder cancer. It is a slow-growing and non-aggressive type of bladder cancer that affects the lining of the tubes in the upper urinary tract.

LG-UTUC usually affects people over the age of 65 and is more common in men than women. It is also more prevalent in individuals with a history of smoking.

Signs and Symptoms of Low-Grade Upper Tract Urothelial Cancer (LG-UTUC)

Early symptoms of LG-UTUC can be difficult to recognize. Symptoms may include:

  • Pain or burning sensation during urination
  • Frequent, difficult, or painful urination
  • Blood in the urine (hematuria), although this is often absent
  • Fatigue
  • Loss of appetite
  • Weight loss
  • Fever
  • Anemia (low red blood cell count)

Diagnosis of Low-Grade Upper Tract Urothelial Cancer (LG-UTUC)

If your doctor suspects LG-UTUC, he or she will order imaging tests such as CT scans, MRI scans, and ultrasound to look for a tumor in the upper urinary tract. Your doctor may also order cystoscopy, which is an examination of the bladder using a thin instrument with a camera attached.

After imaging tests, your doctor may collect a sample of cells from the suspected tumor. The sample is then analyzed in a lab to determine whether cancer is present. If the findings are positive, further tests will be done to determine the stage of the cancer.

Treatment of Low-Grade Upper Tract Urothelial Cancer (LG-UTUC)

The usual treatment for LG-UTUC is radical nephroureterectomy, which involves surgically removing the cancer and some surrounding tissue. In some cases, chemotherapy and/or radiation therapy may be used to treat the cancer.

Outlook for Low-Grade Upper Tract Urothelial Cancer (LG-UTUC)

The outlook for LG-UTUC depends on several factors, including the stage and grade of the cancer, the age and general health of the patient, and the treatments used. In most cases, LG-UTUC can be successfully treated if caught early.