Histiocytic lymphoma
What is Histiocytic Lymphoma?
Histiocytic lymphoma is a rare and aggressive type of non-Hodgkin's lymphoma, an cancer of the lymphatic system. Histiocytic lymphoma is caused by an overabundance of abnormal white blood cells called histiocytes. These cells are called monocytes and have a specific function in the lymphatic system, acting as scavengers to collect and remove debris from infection.
The exact cause of this type of lymphoma is not known, and it is unclear if there is any genetic predisposition. Histiocytic lymphoma usually presents itself initially with swelling of lymph nodes, which can be seen around the neck, armpits, and groin. Additionally, people with histiocytic lymphoma may experience fever, night sweats, and fatigue.
The most common treatment is chemotherapy using drugs that attack the cancerous cells. Some patients may also need to have additional treatment such as radiation, surgery and/or bone-marrow transplantation. The prognosis for histiocytic lymphoma varies from person to person, but it is generally considered a treatable form of non-Hodgkin's lymphoma.
Symptoms of Histiocytic Lymphoma
The most common symptom of histiocytic lymphoma is swollen lymph nodes. These may be felt in the neck, armpits, and groin and can vary in size. Other common symptoms include:
- Fatigue
- Fever
- Night sweats
- Weight loss
- Enlarged liver and/or spleen
- Lack of appetite
Diagnosis and Treatment of Histiocytic Lymphoma
Diagnosis of histiocytic lymphoma is based on a physical exam and laboratory tests such as a complete blood count, a lymph node biopsy, and bone marrow tests. Treatment is typically through chemotherapy, radiation, surgery, and/or bone marrow transplantation. Prognosis depends on the type and extent of the disease, and how well the patient responds to treatment.