Antithyroglobulin antibody test

What Is an antithyroglobulin antibody Test?

An antithyroglobulin antibody (TgAb) test is a blood test used to evaluate a person for an overactive thyroid, also known as hyperthyroidism. The test measures the level of the antithyroglobulin (TgAb) antibody in the blood.

Preparation for the Test

In general, there is no special preparation required for an antithyroglobulin antibody test. Keeping the appointment and being well-rested are the most important things for the patient to do for the procedure.


The antithyroglobulin antibody test is performed in a doctor’s office or a laboratory. The medical provider will draw a sample of blood from a vein in the arm or hand. The blood is then sent to a laboratory for testing.

Types of Antithyroglobulin Antibody Tests

There are several sub-types of antithyroglobulin antibody tests. These tests typically measure the levels of specific autoantibodies, or antibodies that attack healthy cells of the body. These antibodies include:

  • Thyroid Peroxidase Antibodies (TPOAb)
  • Thyroglobulin Antibodies (TgAb)
  • Serum T4 Ab/T4 Immune Binding
  • T3 Uptake/T3 Immune Binding

Risks and Complications

Generally, there are few risks associated with having an antithyroglobulin antibody test. However, the most common risk is pain and irritation associated with the needle poke of taking the blood sample. Occasionally, the patient may experience bruising or Minor bleeding from the sample site.

Reasons For Testing

An antithyroglobulin antibody test is used to diagnose and monitor hyperthyroidism. Symptoms of hyperthyroidism include:

  • Rapid heartbeat
  • Weight loss
  • Sweating
  • Muscle Weakness
  • Nervousness
  • Fatigue
  • Goiter

An antithyroglobulin antibody test can also be used to identify individuals at a higher risk of developing thyroid cancer.

When To Get Tested

Doctors typically order an antithyroglobulin antibody test when a patient is exhibiting symptoms of hyperthyroidism or if they have a family history of thyroid disease. In addition, the test may be ordered if a person’s thyroid stimulating hormone (TSH) levels are abnormal or if they have a goiter.