Refractory gestational trophoblastic disease

Refractory Gestational Trophoblastic Disease

Gestational trophoblastic disease (GTD) is an abnormal growth of cells that usually develop from a fertilized egg. These cancerous cells can grow quickly and spread to other parts of the body, and if left untreated can lead to serious health complications. Refractory gestational trophoblastic disease (RGTD) is a rare form of GTD that is resistant to initial treatments.

RGTD is a notoriously hard to diagnose and treat condition due to its rarity and lack of specific criteria. There is no known definitive cause of the condition, which makes it even more difficult to diagnose and treat. Patients who have RGTD typically experience abnormal vaginal bleeding, persistent molar-like pregnancy symptoms, enlarged uterus, and persistent elevation of HCG levels.

Due to the lack of reliable information on RGTD, treatment options are often limited. Initial treatments often consist of chemotherapy and surgical options. In some cases, a combination of both treatments may be recommended.

Types of Treatment Options

Chemotherapy is the most common form of treatment for RGTD and includes drugs such as methotrexate, actinomycin D, etoposide, and vincristine. These drugs work to stop the cancer’s growth and can be used as single agents or in combination. The efficacy of these drugs varies from person to person and must be closely monitored to assess if the treatment is effective.

Surgery is another form of treatment that may be necessary if chemotherapy does not work. Surgery can be used both to remove any tumors that may be present and to monitor the disease status. This approach may involve invasive procedures to remove the entire uterus, a hysterectomy, or a pelvic lymphadenectomy.

Finally, radiation therapy is another option for treating RGTD. Radiation has been shown to be quite effective in treating some forms of GTD and can be used to shrink large tumors or target diseased areas in the body. Radiation may also be used to alleviate any symptoms that a patient is experiencing as a result of their condition.


In many cases, early diagnosis and treatment are essential in treating RGTD. While the prognosis for some types of GTD can be quite poor, patients with RGTD often have a much better prognosis. With the right combination of treatments and regular monitoring, it is possible for patients to achieve remission or even a complete cure in some cases.

It is important for anyone experiencing unusual symptoms to consult a doctor as soon as possible. While RGTD is considered to be a rare disease, early intervention is essential in increasing the chances of successful treatment and remission.