Mobilization of hematopoietic stem cells therapy

Mobilization of Hematopoietic Stem Cells for Therapeutic Purposes

The mobilization of hematopoietic stem cells (HSCs) has revolutionized the way we treat and manage diseases that require stem cell transplantation, such as certain cancers like leukaemia and lymphomas. The technology also offers immense potential in the therapeutic use of HSCs to treat a wide range of conditions from ischemic vascular diseases, degenerative diseases, genetic disorders, to autoimmune diseases.

Mobilization of HSCs is done by the administration of drugs known as chemoattractants to the patient, which helps the stem cells circulate freely in the peripheral bloodstream. The chemoattractants work by releasing particular hormones, known as cytokines, which act on the stem cells present in the bone marrow, tricking them to leave their home in bone marrow and get into the bloodstream. Subsequently, these mobilized stem cells can be harvested from the peripheral blood using various techniques such as apheresis and leukapheresis.

Once the mobilized stem cells are harvested, the next step is their transplantation. Depending on the patient’s needs, these cells can be transplanted into the patient either intravenously or directly into the affected organs. Intravenous transplantation is the most common way of transplanting HSCs, as it is the safer and easier option. Direct organ transplantation of HSCs is suitable for severe conditions in which the released cytokines can help to rejuvenate the organ or tissue.

Stem cells rely on the patient’s own metabolism for their growth and development. Thus, mobilization of HSCs for therapeutic purposes can be used in many instances to improve a patient’s overall health condition and can even be used to reverse the severity of the condition. Some of the conditions that HSCs have been successfully mobilized for include ischemic vascular diseases, degenerative diseases, genetic disorders, autoimmune diseases, and even cancer.

Benefits of HSC Mobilization for Therapeutic Purposes

  • Non-invasive procedure: Unlike other procedures, HSC mobilization does not require any kind of surgery, removing any associated risks.
  • Lower risk of rejection: HSCs are harvested from the patient’s own body, eliminating the risk of rejection due to non-compatibility with the donor.
  • Effective: HSCs are a powerful and efficient therapeutic tool as they can be used to target multiple organs and tissues.
  • Rapid Healing: HSCs can rapidly heal and regenerate damaged tissues, due to their high rate of cell division.
  • Severe allergic reaction
  • Infection and inflammatory reaction due to internal prosthetic device
  • Esophageal Candidiasis
  • Cognitive Impairments
  • Babesiosis
  • Axillary nerve block therapy
  • Hormone Therapy
  • Refractory Small cell lung cancer
  • Neuromyelitis Optica Spectrum Disorder
  • Itching of the throat
  • Alpha-1 antitrypsin blood test
  • Lactate dehydrogenase test
  • Nasal Swab
  • Insulin in Blood
  • RBC nuclear scan
  • Blood differential test
  • Calcium in Urine Test
  • Ketones in Urine
  • PET scan
  • Gum biopsy