Locally Advanced Epithelioid Sarcoma

What is Locally Advanced Epithelioid Sarcoma?

Locally advanced epithelioid sarcoma (LAES) is a rare type of tumors that affects soft connective tissues such as fat, muscle, and nerve. It is a slow-growing tumor and often appears as a mass that is rock-hard. LAES is typically found in the arms and legs, near the external genitals, and around the rectum.

The extent of LAES at diagnosis can range from very localized to a more advanced stage where the tumor has grown and spread to other parts of the body. Treatment for LAES usually involves surgery and/or radiation therapy and may also include chemotherapy.

Signs and Symptoms

The most common symptom of LAES is swelling or a mass in the arms or legs, although it may also occur near the genitals or rectum. Other symptoms may include pain, numbness, tingling, and the development of lumps. LAES may also cause changes in the skin such as redness, breakdown, thickening, and ulceration.

Diagnosis and Treatment

LAES is diagnosed with imaging tests such as an X-ray, CT scan, or MRI. A biopsy of the mass may be needed to confirm the diagnosis. Treatment for LAES may involve one or more of the following:

  • Surgery.
  • Radiation therapy.
  • Chemotherapy.
  • Targeted therapy.
  • Immunotherapy.

Surgery is usually the first course of treatment for LAES and aims to remove the tumor completely. If the tumor cannot be removed, radiation therapy and/or chemotherapy may be used to shrink the tumor.


The outlook for people with LAES depends on the stage and size of the tumor, as well as the individual's overall health. The overall 5-year survival rate for LAES is about 40%, but this increases to around 70-90% for localized tumors.

It is important for people with LAES to have regular follow-up appointments with their doctor to monitor the progress of the disease. Early detection and treatment can help improve outcomes and reduce the risk of recurrence.