Refractory Advanced Ovarian Cancer

Refractory Advanced Ovarian Cancer: A Comprehensive Overview

Refractory advanced ovarian cancer is a form of cancer that resists treatment and is often terminal. The disease is often a cause of mortality in women and usually affects those over 50 years of age. This type of ovarian cancer is classified into three types: refractory, relapsed, and recurrent. Each type has different treatment options, and the approach typically depends on a woman’s age, stage of the disease, and personal history. This article provides a comprehensive overview of refractory advanced ovarian cancer.

Risk Factors For Refractory Advanced Ovarian Cancer

There are several factors that can increase a woman’s risk of developing refractory advanced ovarian cancer. These include genetic factors such as mutations in the BRCA 1 or BRCA 2 genes, a family history of ovarian cancer, age, and smoking. Additionally, obesity and a sedentary lifestyle are also considered risk factors for the disease.

Signs and Symptoms

The signs and symptoms of refractory advanced ovarian cancer are often vague and can vary from person to person. Common symptoms include abdominal bloating, pelvic pain, constipation or diarrhea, fatigue, and back pain.

Diagnosis and Treatment

Diagnosing refractory advanced ovarian cancer requires comprehensive testing, including imaging studies such as computed tomography and magnetic resonance imaging. In addition to imaging, abdominal biopsy and tumor marker tests can also help to identify the disease. Treatment for refractory advanced ovarian cancer may include surgery, chemotherapy, radiation therapy, and targeted therapy.

Prevention and Management

Since the risk factors for refractory advanced ovarian cancer cannot be changed, management focuses on early detection and prompt treatment. Being aware of one’s risk factors and undergoing regular screening can help to detect the disease as early as possible.


Refractory advanced ovarian cancer is a serious illness with a poor prognosis. However, with early detection and treatment, the outcomes can be improved. Additionally, there are support systems available to help those affected by the disease manage their condition and its treatment.