Sulindac Sulfone

Sulindac Sulfone

Uses

Investigated for use/treatment in adenomatous polyposis coli, lung cancer, prostate cancer, colon polyps, Barrett's esophagus disease, and pediatric indications.

How Sulindac Sulfone works

Sulindac Sulfone is a sulindac derivative of a class of compounds called selective apoptotic anti-neoplastic drugs (SAANDs), which inhibit the enzyme cyclic guanosine monophosphodiesterase (cGMP - PDE). Sulindac Sulfone is specific for apoptotic effects in precancerous and cancerous colorectal cells due to their overexpression of cGMP. Sustained elevation of cGMP and protein kinase G (PKG) activation may be also implicated in the induction of apoptosis by Sulindac Sulfone.

Sulindac Sulfone

Trade Name	Sulindac Sulfone
Generic	Exisulind
Exisulind Other Names	Exisulind, Sulindac sulfone
Type
Formula	C20H17FO4S
Weight	Average: 372.41 Monoisotopic: 372.083158364
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	August 5, 2021 at 12:40 pm

Structure

Table Of contents

• Sulindac Sulfone
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Innovators Monograph

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