Sulindac Sulfone

Sulindac Sulfone

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Uses

Investigated for use/treatment in adenomatous polyposis coli, lung cancer, prostate cancer, colon polyps, Barrett's esophagus disease, and pediatric indications.

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How Sulindac Sulfone works

Sulindac Sulfone is a sulindac derivative of a class of compounds called selective apoptotic anti-neoplastic drugs (SAANDs), which inhibit the enzyme cyclic guanosine monophosphodiesterase (cGMP - PDE). Sulindac Sulfone is specific for apoptotic effects in precancerous and cancerous colorectal cells due to their overexpression of cGMP. Sustained elevation of cGMP and protein kinase G (PKG) activation may be also implicated in the induction of apoptosis by Sulindac Sulfone.

Sulindac Sulfone

Trade Name Sulindac Sulfone
Generic Exisulind
Exisulind Other Names Exisulind, Sulindac sulfone
Type
Formula C20H17FO4S
Weight Average: 372.41
Monoisotopic: 372.083158364
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: August 5, 2021 at 12:40 pm

Structure

Sulindac Sulfone
Exisulind Structure
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Download Bissoy App to talk Doctor online
Download Bissoy App to talk Doctor online
Download Bissoy App to talk Doctor online
Download Bissoy App to talk Doctor online
Download Bissoy App to talk Doctor online

Innovators Monograph

You find simplified version here Sulindac Sulfone