Sulindac Sulfone
Sulindac Sulfone
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Uses
Investigated for use/treatment in adenomatous polyposis coli, lung cancer, prostate cancer, colon polyps, Barrett's esophagus disease, and pediatric indications.
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How Sulindac Sulfone works
Sulindac Sulfone is a sulindac derivative of a class of compounds called selective apoptotic anti-neoplastic drugs (SAANDs), which inhibit the enzyme cyclic guanosine monophosphodiesterase (cGMP - PDE). Sulindac Sulfone is specific for apoptotic effects in precancerous and cancerous colorectal cells due to their overexpression of cGMP. Sustained elevation of cGMP and protein kinase G (PKG) activation may be also implicated in the induction of apoptosis by Sulindac Sulfone.
Sulindac Sulfone
Trade Name | Sulindac Sulfone |
Generic | Exisulind |
Exisulind Other Names | Exisulind, Sulindac sulfone |
Type | |
Formula | C20H17FO4S |
Weight | Average: 372.41 Monoisotopic: 372.083158364 |
Groups | Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | August 5, 2021 at 12:40 pm |
Structure
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Innovators Monograph
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