Amelubant Uses, Dosage, Side Effects, Food Interaction and all others data.

Trade Name Amelubant
Generic Amelubant
Amelubant Other Names Amelubant
Formula C33H34N2O5
Weight Average: 538.644
Monoisotopic: 538.246772203
Groups Investigational
Therapeutic Class
Available Country
Last Updated: September 19, 2023 at 7:00 am


Investigated for use/treatment in asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and rheumatoid arthritis.

How Amelubant works

Amelubant is a long-acting oral Leukotriene B4 (LTB4) receptor antagonist. Amelubant is a prodrug which is metabolized by ubiquitous esterases to BIIL 260 and its glucuronidated metabolite BIIL 315.14. BIIL 260 and BIIL 315.14 interact directly with the LTB4 receptors. LTB4 is a chemotactic factor for immune cells and potentiates the immune response. The G-protein coupled receptors BLT1, (high affinity for LTB4, expressed in most leukocytes) and BLT2 (low affinity for LTB4) are responsible for mediating LTB4's effects.

Innovators Monograph

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