Amelubant

Amelubant

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Uses

Investigated for use/treatment in asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and rheumatoid arthritis.

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How Amelubant works

Amelubant is a long-acting oral Leukotriene B4 (LTB4) receptor antagonist. Amelubant is a prodrug which is metabolized by ubiquitous esterases to BIIL 260 and its glucuronidated metabolite BIIL 315.14. BIIL 260 and BIIL 315.14 interact directly with the LTB4 receptors. LTB4 is a chemotactic factor for immune cells and potentiates the immune response. The G-protein coupled receptors BLT1, (high affinity for LTB4, expressed in most leukocytes) and BLT2 (low affinity for LTB4) are responsible for mediating LTB4's effects.

Amelubant

Trade Name Amelubant
Generic Amelubant
Amelubant Other Names Amelubant
Type
Formula C33H34N2O5
Weight Average: 538.644
Monoisotopic: 538.246772203
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: August 5, 2021 at 12:40 pm

Structure

Amelubant
Amelubant Structure
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Download Bissoy App to talk Doctor online
Download Bissoy App to talk Doctor online
Download Bissoy App to talk Doctor online
Download Bissoy App to talk Doctor online
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Innovators Monograph

You find simplified version here Amelubant