Nitrus Uses, Dosage, Side Effects, Food Interaction and all others data.

Nitrus is a hyperosmotic laxative, given rectally, which usually produces a bowel movement within 15 minutes to 1 hour. Hyperosmotic laxatives encourage bowel movements by drawing water into the bowel from surrounding tissues. This produces a softer stool mass and increased bowel action. These products are used for fast, predictable relief of occasional constipation.

Nitrus is commonly classified as an osmotic laxative but may act additionally or alternatively through its local irritant effects; it may also have lubricating and fecal softening actions. Nitrus suppositories usually work within 15 to 30 minutes.

Trade Name Nitrus
Availability Rx and/or OTC
Generic Glycerin
Glycerin Other Names Glycerin, Glycerine, glycérine, Glycerinum, Glycerol, glycérol, Glyzerin, Monoctanoin component D, Ölsüß, Propanetriol, Trihydroxypropane
Related Drugs diphenhydramine, Benadryl, benzonatate, MiraLAX, guaifenesin, Colace, docusate, codeine, Linzess, dextromethorphan
Formula C3H8O3
Weight Average: 92.0938
Monoisotopic: 92.047344122
Groups Approved, Investigational
Therapeutic Class Osmotic purgatives
Manufacturer Icarus Health Care Pvt Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am

How Nitrus works

When administered rectally, glycerin exerts a hygroscopic and/or local irritant action, drawing water from the tissues into the feces and reflexively stimulating evacuation. Nitrus decreases intraocular pressure by creating an osmotic gradient between the blood and intraocular fluid, causing fluid to move out of the aqueous and vitreous humors into the bloodstream.


Nitrus dosage

Children under 2 years: Consult a physician.

Children (2 to 6 years): only 1 Nitrus 1.15 suppository per 24 hours or as directed by a physician.

Adults and Children (From 6 years): only 1 Nitrus 2.30 suppository per 24 hours or as directed by a physician

Insert suppository well up into rectum. Suppository need to melt completely to produce laxative action.

Side Effects

Nitrus when used rectally may cause rectal discomfort or a burning sensation


Glycerol has very low toxicity when ingested ; Rat LD50 (oral)-12600mg/kg Mice LD50 (oral )-4090mg/kg Human TDLo (oral) - 1428mg/kg

Food Interaction

No interactions found.

Volume of Distribution

Nitrus is distributed throughout the blood. Although glycerin generally does not appear in ocular fluids, it may enter the orbital sac when the eye is inflamed, with a consequent decrease in osmotic effect.

Elimination Route

Well absorbed orally, poorly absorbed rectally. Studies in humans and animals indicate glycerol is rapidly absorbed in the intestine and the stomach

Half Life

30 - 45 minutes

Elimination Route

Approx 7-14% of dose is excreted unchanged in the urine within 2.5 hr.

Pregnancy & Breastfeeding use

Pregnancy category C. There are no controlled data in human pregnancy


Sensitivity to the ingredients. Do not use unless the patient to be treated is, in fact, constipated.

Storage Condition

Store below 25° C. Protect from moisture.

Innovators Monograph

You find simplified version here Nitrus


What is Nitrus used for?

Nitrus is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations.

How safe is Nitrus?

Since Nitrus is a form of sugar alcohol that your body cannot fully absorb, consuming too much either alone or through foods may also lead to gas and diarrhea. Vegetable glycerin is generally considered safe.

How does Nitrus work?

Nitrus works by causing the intestines to hold more water, which softens the stool.

What are the common side effects of Nitrus?

Common side effects of brad are include:

  • Excessive bowel activity.
  • Cramping.
  • Rectal irritation.
  • Cramping rectal pain.

Can I mix alcohol and Nitrus?

Mix 12 fluid ounces of alcohol with 2 teaspoons of Nitrus.

What happens if I drink Nitrus?

When ingested, vegetable Nitrus may cause headaches, dizziness, nausea, vomiting and excessive thirst in some people.

Is Nitrus safe during pregnancy?

Nitrus is only recommended for use during pregnancy when benefit outweighs risk.

Is Nitrus safe during breastfeeding?

It is not known whether Nitrus enters breast milk. It is most likely compatible with breastfeeding.

How do I take Nitrus?

Use your finger or the applicator provided to insert the suppository. Lie on your left side with your lower leg straight and your upper leg bent. Gently insert the suppository pointed tip first into your rectum, about 1/2 inch for a child or 1 inch for an adult. For best results, stay lying down for a few minutes.

How long should Nitrus take to work?

Nitrus belongs to a class of drugs known as hyperosmotic laxatives. This effect usually results in a bowel movement within 15 to 60 minutes. For adults, the normal frequency of bowel movements varies from once daily to 1 to 2 times weekly.

When should I take Nitrus?

For better muscle pumps, take 10–30 grams of Nitrus with 20–32 ounces of water about one hour before workouts. Also be sure to take creatine with your pre- and postworkout shakes for a synergistic effect.

How often can I take Nitrus?

Since this medicine is usually given only once as needed, you will not be on a dosing schedule. Do not use Nitrus rectal more than once in a 24-hour period.

Who should not use Nitrus?

Stop using glycerin rectal and call your doctor at once if you have: severe stomach pain or cramping; rectal bleeding; or. no bowel movement within 1 hour after use.

Does Nitrus affect blood pressure?

Nitrus is used as a peroral treatment of increased intraocular and intracranial pressure due to its osmotic effect despite the potential increase in blood pressure and blood glucose.

Is Nitrus bad for kidneys?

Nitrus administration caused severe renal dysfunction, which included marked renal oxidative stress, significantly increased blood urea nitrogen (BUN) and serum creatinine levels.

What happens if I miss a dose?

If you use this medicine on a regular basis, use a missed dose as soon as you think about it.
If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
Do not use 2 doses at the same time or extra doses.

What happens if I overdose?

An overdose of Nitrus rectal is not expected to be dangerous. Seek emergency medical attention if anyone has accidentally swallowed the medication.

Can Nitrus bad for skin?

Nitrus is typically safe to use on the skin, and many people use cosmetic products containing this ingredient without issue.

Can Nitrus remove pimples?

Nitrus cleanses the skin pores and removes dirt. It keeps the skin healthy. Nitrus reduces acne and keeps the skin pores clean.

Is Nitrus good for health?

Due to its ability to retain moisture, Nitrus may be beneficial for skin health, digestive health, and improving athletic performance.

Does Nitrus darken skin?

No, Nitrus does not darken your skin. Nitrus is an ingredient that is actually found in some whitening products.

Does Nitrus expire?

100% pure Vegetable Nitrus does not oxidize or go bad, given that it is stored in a none transparent container in a cool, dry place away from sunlight and covered by an airtight lid.

Is Nitrus good for my hair?

It moisturizes and is known to prevent breakage, especially on hair that isn't chemically treated. Since it helps draw moisture from the air onto your hair and is easily soluble in water, Nitrus can serve as a great deep conditione.

*** Taking medicines without doctor's advice can cause long-term problems.