Glycerin Uses, Dosage, Side Effects, Food Interaction and all others data.

Glycerin is a hyperosmotic laxative, given rectally, which usually produces a bowel movement within 15 minutes to 1 hour. Hyperosmotic laxatives encourage bowel movements by drawing water into the bowel from surrounding tissues. This produces a softer stool mass and increased bowel action. These products are used for fast, predictable relief of occasional constipation.

Glycerin is commonly classified as an osmotic laxative but may act additionally or alternatively through its local irritant effects; it may also have lubricating and fecal softening actions. Glycerin suppositories usually work within 15 to 30 minutes.

Trade Name Glycerin
Availability Rx and/or OTC
Generic Glycerin
Glycerin Other Names Glycerin, Glycerine, glycérine, Glycerinum, Glycerol, glycérol, Glyzerin, Monoctanoin component D, Ölsüß, Propanetriol, Trihydroxypropane
Related Drugs diphenhydramine, Benadryl, benzonatate, MiraLAX, guaifenesin, Colace, docusate, codeine, Linzess, dextromethorphan
Type Liquid
Formula C3H8O3
Weight Average: 92.0938
Monoisotopic: 92.047344122
Groups Approved, Investigational
Therapeutic Class Osmotic purgatives
Manufacturer Mediplus Pharma, Khona Enterprises
Available Country India
Last Updated: September 19, 2023 at 7:00 am

How Glycerin works

When administered rectally, glycerin exerts a hygroscopic and/or local irritant action, drawing water from the tissues into the feces and reflexively stimulating evacuation. Glycerin decreases intraocular pressure by creating an osmotic gradient between the blood and intraocular fluid, causing fluid to move out of the aqueous and vitreous humors into the bloodstream.


Glycerin dosage

Children under 2 years: Consult a physician.

Children (2 to 6 years): only 1 Glycerin 1.15 suppository per 24 hours or as directed by a physician.

Adults and Children (From 6 years): only 1 Glycerin 2.30 suppository per 24 hours or as directed by a physician

Insert suppository well up into rectum. Suppository need to melt completely to produce laxative action.

Side Effects

Glycerin when used rectally may cause rectal discomfort or a burning sensation


Glycerol has very low toxicity when ingested ; Rat LD50 (oral)-12600mg/kg Mice LD50 (oral )-4090mg/kg Human TDLo (oral) - 1428mg/kg

Food Interaction

No interactions found.

Volume of Distribution

Glycerin is distributed throughout the blood. Although glycerin generally does not appear in ocular fluids, it may enter the orbital sac when the eye is inflamed, with a consequent decrease in osmotic effect.

Elimination Route

Well absorbed orally, poorly absorbed rectally. Studies in humans and animals indicate glycerol is rapidly absorbed in the intestine and the stomach

Half Life

30 - 45 minutes

Elimination Route

Approx 7-14% of dose is excreted unchanged in the urine within 2.5 hr.

Pregnancy & Breastfeeding use

Pregnancy category C. There are no controlled data in human pregnancy


Sensitivity to the ingredients. Do not use unless the patient to be treated is, in fact, constipated.

Storage Condition

Store below 25° C. Protect from moisture.

Innovators Monograph

You find simplified version here Glycerin


What is Glycerin used for?

Glycerin is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations.

How safe is Glycerin?

Since Glycerin is a form of sugar alcohol that your body cannot fully absorb, consuming too much either alone or through foods may also lead to gas and diarrhea. Vegetable glycerin is generally considered safe.

How does Glycerin work?

Glycerin works by causing the intestines to hold more water, which softens the stool.

What are the common side effects of Glycerin?

Common side effects of brad are include:

  • Excessive bowel activity.
  • Cramping.
  • Rectal irritation.
  • Cramping rectal pain.

Can I mix alcohol and Glycerin?

Mix 12 fluid ounces of alcohol with 2 teaspoons of Glycerin.

What happens if I drink Glycerin?

When ingested, vegetable Glycerin may cause headaches, dizziness, nausea, vomiting and excessive thirst in some people.

Is Glycerin safe during pregnancy?

Glycerin is only recommended for use during pregnancy when benefit outweighs risk.

Is Glycerin safe during breastfeeding?

It is not known whether Glycerin enters breast milk. It is most likely compatible with breastfeeding.

How do I take Glycerin?

Use your finger or the applicator provided to insert the suppository. Lie on your left side with your lower leg straight and your upper leg bent. Gently insert the suppository pointed tip first into your rectum, about 1/2 inch for a child or 1 inch for an adult. For best results, stay lying down for a few minutes.

How long should Glycerin take to work?

Glycerin belongs to a class of drugs known as hyperosmotic laxatives. This effect usually results in a bowel movement within 15 to 60 minutes. For adults, the normal frequency of bowel movements varies from once daily to 1 to 2 times weekly.

When should I take Glycerin?

For better muscle pumps, take 10–30 grams of Glycerin with 20–32 ounces of water about one hour before workouts. Also be sure to take creatine with your pre- and postworkout shakes for a synergistic effect.

How often can I take Glycerin?

Since this medicine is usually given only once as needed, you will not be on a dosing schedule. Do not use Glycerin rectal more than once in a 24-hour period.

Who should not use Glycerin?

Stop using glycerin rectal and call your doctor at once if you have: severe stomach pain or cramping; rectal bleeding; or. no bowel movement within 1 hour after use.

Does Glycerin affect blood pressure?

Glycerin is used as a peroral treatment of increased intraocular and intracranial pressure due to its osmotic effect despite the potential increase in blood pressure and blood glucose.

Is Glycerin bad for kidneys?

Glycerin administration caused severe renal dysfunction, which included marked renal oxidative stress, significantly increased blood urea nitrogen (BUN) and serum creatinine levels.

What happens if I miss a dose?

If you use this medicine on a regular basis, use a missed dose as soon as you think about it.
If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
Do not use 2 doses at the same time or extra doses.

What happens if I overdose?

An overdose of Glycerin rectal is not expected to be dangerous. Seek emergency medical attention if anyone has accidentally swallowed the medication.

Can Glycerin bad for skin?

Glycerin is typically safe to use on the skin, and many people use cosmetic products containing this ingredient without issue.

Can Glycerin remove pimples?

Glycerin cleanses the skin pores and removes dirt. It keeps the skin healthy. Glycerin reduces acne and keeps the skin pores clean.

Is Glycerin good for health?

Due to its ability to retain moisture, Glycerin may be beneficial for skin health, digestive health, and improving athletic performance.

Does Glycerin darken skin?

No, Glycerin does not darken your skin. Glycerin is an ingredient that is actually found in some whitening products.

Does Glycerin expire?

100% pure Vegetable Glycerin does not oxidize or go bad, given that it is stored in a none transparent container in a cool, dry place away from sunlight and covered by an airtight lid.

Is Glycerin good for my hair?

It moisturizes and is known to prevent breakage, especially on hair that isn't chemically treated. Since it helps draw moisture from the air onto your hair and is easily soluble in water, Glycerin can serve as a great deep conditione.

*** Taking medicines without doctor's advice can cause long-term problems.