Nexcon is a sterile, semisynthetic, broad-spectrum, 3rd generation cephalosporin antibiotic for intravenous or intramuscular administration. The bactericidal activity of Nexcon results from inhibition of cell wall synthesis. Nexcon has a high degree of stability in the presence of beta-lactamases both penicillinases and cephalosporinases of gram-negative and gram- positive bacteria.
Nexcon is used for the treatment of the following infections when caused by susceptible organisms:
Lower Respiratory Tract Infections caused by Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, E. coli, Enterobacter aerogenes, Proteus mirabilis, Serratia marcescens.
Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase producing strains), Moraxella catarrhalis (including beta-lactamase producing strains).
Skin and Skin Structure Infections caused by Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Viridans group streptococci, E. coli, Enterobacter cloacae, Klebsiella oxytoca, Klebsiella pneumoniae, Proteus mirabilis, Morganella morganii, Pseudomonas aeruginosa, Serratia marcescens, Acinetobacter calcoaceticus, Bacteroides fragilis, Peptostreptococcus species.
Urinary Tract Infections (complicated and uncomplicated) caused by E. coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Klebsiella pneumoniae.
Uncomplicated Gonorrhea (cervical, urethral, pharyngial and rectal) caused by Neisseria gonorrhoeae, including both penicillinase- and nonpenicillinase-producing strains, and pharyngeal gonorrhea caused by nonpenicillinase-producing strains of Neisseria gonorrhoeae.
Pelvic Inflammatory Disease caused by Neisseria gonorrhoeae.
Bacterial Septicemia caused by Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Haemophilus influenzae, Klebsiella pneumoniae.
Bone and Joint Infections caused by Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species.
Intra-abdominal Infections caused by E. coli, Klebsiella pneumoniae, Bacteroides fragilis, Clostridium species, Peptostreptococcus species.
Meningitis caused by Haemophilus influenzae, Neisseria meningitidis, Streptococcus pneumoniae. Nexcon has also been used successfully in a limited number of cases of meningitis and shunt infection caused by Staphylococcus epidermidis and E. coli.
Surgical Prophylaxis: The preoperative administration of a single 1 gm dose of Nexcon may reduce the incidence of postoperative infections in patients undergoing surgical procedures classified as contaminated or potentially contaminated.
Nexcon is also used to associated treatment for these conditions: Arthritis gonococcal, Bacterial Endocarditis, Bacterial Infections, Bacterial Sepsis, Bacterial Sinusitis, Bone and Joint Infections, Brain abscess, Chancroid, Community Acquired Pneumonia (CAP), Conjunctivitis gonococcal neonatal, Epididymitis, Epiglottitis, Gonococcal infection of pharynx, Gonococcal pelvic inflammatory disease, Intra-Abdominal Infections, Lower respiratory tract infection bacterial, Lyme Neuroborreliosis, Meningitis, Bacterial, Ophthalmia neonatorum due to gonococcus, Postoperative Infections, Prosthetic Joint Infection, Salmonella Typhi Infection, Septic Arthritis, Shigellosis, Skin and Subcutaneous Tissue Bacterial Infections, Syphilis, Vulvovaginitis gonococcal, Whipple Disease, Bacterial otitis media, Complicated Bacterial Urinary Tract Infections, Susceptible Bacterial Infections, Uncomplicated Gonorrhea, Uncomplicated Urinary tract infection bacterial
|Ceftriaxone Other Names||Ceftriaxona, Ceftriaxone, Ceftriaxonum, Rocephin|
Ceftriaxone is 95% protein bound.
|Therapeutic Class||Third generation Cephalosporins|
|Manufacturer||Nectar Lifesciences Ltd|
|Last Updated:||June 23, 2021 at 9:00 am|
Generally, Nexcon should be taken once or equally devided twice a day for 4-14 days. Nexcon therapy should be continued for at least 2 days after the sign and symptoms of infection have disappeared.
The usual duration of therapy is 4 to 14 days; in complicated infections longer therapy may be required. No dosage adjustment is required for patients with renal or hepatic impairment.
Use the solution immediately after reconstitution of powder.
Generally Nexcon is well tolerated. However, few side effects including nausea, vomiting, diarrhea, dizziness and fever may occur.
Nexcon should be administered with caution to individuals with a history of gastrointestinal disease, particularly colitis.
May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate. May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase serum level with probenecid.
Food InteractionNo interactions found.
Volume of Distribution
The apparent volume of distribution of an intravenous or intramuscular dose in healthy patients is 5.78 to 13.5 L. The volume of distribution of an intravenous or intramuscular dose in septic patients is 6.48 to 35.2 L. Nexcon has good enough CSF penetration to be used as an effective treatment of bacterial meningitis.
The elimination half-life of ceftriaxone is 5.8-8.7 hours. The half-life of ceftriaxone in the middle ear fluid has been estimated to be 25 hours.
The plasma clearance of ceftriaxone in healthy adults receiving a 0.15-3g dose is 0.58 to 1.45 L/hour. The renal clearance of ceftriaxone is 0.32 to 0.73 L/hour. In intensive care unit patients, ceftriaxone's total drug clearance was 0.96L/h (0.55-1.28 L/h), and unbound drug clearance was 1.91 L/h (1.46-6.20 L/h).
Pregnancy & Breastfeeding use
Pregnancy: The safety of Nexcon in the treatment of infections during pregnancy has not been established. Nexcon should only be used during pregnancy if the likely benefit outweighs the potential risk to the fetus and/or the mother.
Lactation: Nexcon is excreted in breast milk at low concentrations. Therefore, caution should be exercised when Nexcon is administered to a nursing mother.
Nexcon should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics. It is contraindicated in premature infants during the first 6 weeks of life. Its safety in human pregnancy has not been established. Nexcon is contraindicated in neonates if they require (or are expected to require) treatment with calcium-containing IV solutions, including continuous calcium containing infusions such as parenteral nutrition because of the risk of precipitation of ceftriaxone-calcium.
There is no specific antidote. Treatment of over dosage should be symptomatic.
Store below 25°C, protected from light & moisture. Use reconstituted solutions immediately.
Reconstituted solutions are stable for 6 hours at room temperature and for 24 hours at 2°-8°C. It should not be mixed in the same syringe with any drug other than 1% Lidocaine Hydrochloride injection BP (for IM injection only).
What is Nexcon medicine used for?
Nexcon is a cephalosporin antibiotic. It is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections.
What infections does Nexcon treat?
Nexcon injection is used to treat certain infections caused by bacteria such as gonorrhea (a sexually transmitted disease), pelvic inflammatory disease (infection of the female reproductive organs that may cause infertility), meningitis (infection of the membranes that surround the brain and spinal cord), and infections of the lungs, ears, skin, urinary tract, blood, bones, joints, and abdomen. Nexcon injection is also sometimes given before certain types of surgery to prevent infections that may develop after the operation. Nexcon injection is in a class of medications called cephalosporin antibiotics. It works by killing bacteria.
How is Nexcon administered?
The injection should be administered over 5 minutes, directly into the vein or via the tubing of an intravenous infusion. Nexcon can be administered by intravenous infusion over at least 30 minutes (preferred route) or by slow intravenous injection over 5 minutes.
Where should Nexcon be injected?
The reconstituted solution of Nexcon Sodium should be administered by deep intra-gluteal injection, preferably the ventrogluteal muscle. It is recommended to use a 21 gauge, 1.5″ needle with a 3cc syringe.
Who should not take Nexcon?
A type of blood disorder where the red blood cells burst called hemolytic anemia. Liver problems. disease of the gallbladder. Severe renal impairment.
What are side effects of Nexcon?
- Black, tarry stools.
- chest pain.
- shortness of breath.
- sore throat.
- sores, ulcers, or white spots on the lips or in the mouth.
- swollen glands.
- unusual tiredness or weakness.
Who needs Nexcon?
Nexcon is a cephalosporin antibiotic that is used to treat many kinds of bacterial infections, including severe or life-threatening forms such as E. coli, pneumonia, or meningitis. Nexcon is also used to prevent infection in people having certain types of surgery.
How strong is Nexcon?
Concentrations between 10 mg/mL and 40 mg/mL are recommended; however, lower concentrations may be used if desired. Reconstitute vials with an appropriate IV diluent (see Compatibility And Stability). After reconstitution, each 1 mL of solution contains approximately 100 mg equivalent of Nexcon.
Can I take Nexcon without food?
Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Nexcon, there are no specific foods that you must exclude from your diet when receiving this medication.
Which of the following foods drinks should be avoided during treatment with Nexcon?
Foods that must be avoided while on antibiotic treatment include grapefruit, foods rich in calcium, and alcohol
Can I drink after taking Nexcon?
It is best not to drink alcohol for up to 48 hours after the injection
Can a nursing mother take Nexcon injection?
Nexcon is acceptable in nursing mothers
How many days should ceftriaxone injection be taken?
It is sometimes given as a single dose and sometimes given once or twice a day for 4-14 days, depending on the type of infection being treated. You may receive ceftriaxone injection in a hospital or doctor's office, or you may administer the medication at home.