Redura

Redura Tablet, Dsr Capsule

Redura Sodium is an antiulcerant drug in the class of Proton Pump Inhibitors. Redura Sodium is a substituted benzimidazole which suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase enzyme at the secretory surface of the gastric parietal cell. It is an enteric coated tablet, because of its coated formulation it is highly stable in stomach and because of higher pKa value of Redura Sodium it provides faster onset of action. It blocks the final step of gastric acid secretion.

After oral administration of 20 mg, Redura is absorbed and can be detected in plasma by 1 hour. The effects of food on the absorption of Redura have not been evaluated. Redura is 96.3% bound to human plasma proteins. Redura is primarily metabolized in the liver by Cytochrome P-450 3A (Sulphone metabolite) and 2C19 (Desmethyl Redura). Following a single 20 mg oral dose of Redura, approximately 90% of the drug is eliminated in the urine.The remainder of the dose is excreted in the feaces.

Uses

Short-term treatment in healing and symptomatic relief of duodenal ulcers and erosive or ulcerative Gastroesophageal Reflux Disease (GERD).

Maintaining healing and reducing relapse rates of heartburn symptoms in patients with GERD.

Treatment of daytime and night time heartburn and other symptoms associated with GERD.

Long-term treatment of pathological hypersecretory conditions, including Zollinger Ellison Syndrome.

In combination with Amoxicillin and Clarithromycin to eradicate Helicobacter pylori.

Redura is also used to associated treatment for these conditions: Duodenal Ulcer, Gastric Ulcer, Gastro-esophageal Reflux Disease (GERD), Heartburn, Helicobacter Pylori Infection, NSAID Associated Gastric Ulcers, Non-erosive Reflux Esophagitis Disease (NERD), Vomiting, Zollinger-Ellison Syndrome, Erosive reflux esophagitis

Redura

Trade Name Redura
Generic Rabeprazole
Rabeprazole Other Names Clofezone, Rabeprazole
Type Tablet, Dsr Capsule
Formula C18H21N3O3S
Weight Average: 359.443
Monoisotopic: 359.130362243
Protein binding

96.3% (bound to human plasma proteins)

Therapeutic Class Proton Pump Inhibitor
Manufacturer Orion Biotech Pvt Ltd
Available Country India
Last Updated: June 23, 2021 at 9:00 am

Structure

Redura
Rabeprazole Structure

Dosage

Redura dosage

Healing of Erosive or Ulcerative Gastroesophageal Reflux Disease (GERD): 20 mg to be taken once daily for 4 to 8 weeks. For those patients who have not healed after 8 weeks of treatment, an additional 8 week course may be considered.

Maintenance of Healing of Erosive or Ulcerative Gastroesophageal Reflux Disease (GERD Maintenance): The recommended adult oral dose is 20 mg once daily.

Treatment of Symptomatic Gastroesophageal Reflux Disease (GERD):The recommended adult oral dose is 20 mg once daily for 4 weeks. If symptoms do not resolve completely after 4 weeks, an additional course of treatment may be considered.

Healing of Duodenal Ulcers:The recommended adult oral dose is 20 mg once daily after the morning meal for a period up to four weeks. Most patients with duodenal ulcer heal within four weeks. A few patients may require additional therapy to achieve healing.

Helicobacter pylori Eradication: To Reduce the Risk of Duodenal Ulcer Recurrence-

  • Redura Sodium 20 mg Twice Daily for 7 Days
  • Amoxicillin 1000 mg Twice Daily for 7 Days
  • Clarithromycin 500 mg Twice Daily for 7 Days

All three medications should be taken twice daily with the morning and evening meals. It is important that patients comply with the full 7-day regimen.

Treatment of Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome: The dosage of Redura Sodium in patients with pathologic hypersecretory conditions varies with the individual patient. The recommended adult oral starting dose is 60 mg once a day. Doses should be adjusted to individual patient needs and should continue for as long as clinically indicated. Some patients may require divided doses. Doses up to 100 mg QD and 60 mg BID have been administered. Some patients with Zollinger-Ellision syndrome have been treated continuously with Redura Sodium for up to one year.

Side Effects

Redura Sodium may sometimes cause headache, diarrhoea, abdominal pain, vomiting, constipation, dry mouth, increased or decreased appetite, muscle pain, drowsiness and dizziness.

Precaution

Administration of Redura Sodium to patients with mild to moderate liver impairment resulted in increased exposure and decreased elimination. Caution should be exercised in patients with severe hepatic impairment.

Interaction

Redura is metabolized by the Cytochrome P-450 (CYP-450) drug metabolizing enzyme system. Redura does not have clinically significant interactions with other drugs metabolized by the CYP-450 system,such as Warfarin and Theophylline given as single oral dose, Diazepam as a single intravenous dose, and Phenytoin given as a single intravenous dose. In normal subjects, co-administration of Redura 20 mg QD resulted in an approximately 30% decrease in the bioavailability of Ketoconazole and increase in the AUC and Cmax for digoxin of 90% and 29% respectively.

Food Interaction

  • Take with or without food. Food delays drug absorption, but not to a clinically significant extent.

Half Life

1-2 hours (in plasma)

Pregnancy & Breastfeeding use

Redura is FDA Pregnancy Category B. No data is available on administration of Redura to pregnant women. However this drug should be used during pregnancy, only if clearly needed. There are no data on the excretion of Redura into the breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the benefit of the drug to the mother.

Contraindication

Redura Sodium is contraindicated in patient with known hypersensitivity to Redura or to any component in the product.

Special Warning

Use in pediatric patients: The safety and effectiveness of Redura in pediatric patients have not been established.

Acute Overdose

There has been no experience with large overdoses with Redura. No specific antidote for Redura is known. Redura is extensively protein bound and is not readily dialyzable. In the event of overdosage, treatment should be symptomatic and supportive.

Storage Condition

Store below 25°C, protected from light and moisture. Keep all medicines out of the reach of the children.

Innovators Monograph

Redura contains Rabeprazole see full prescribing information from innovator Monograph

FAQ

What is Redura used for?

Redura used for heartburn, acid reflux and gastro-oesophageal reflux disease when you keep getting acid reflux. Redura is also taken to prevent and treat stomach ulcers. Redura reduces the amount of acid your stomach makes.

How safe is Redura?

Redura is efficacious in gastro-esophageal reflux disease (GERD) and other acid-related diseases. Long-term use of Redura was confirmed to be safe in studies of two to five-year maintenance therapy for GERD.

What are side effects of Redura?

Common side effects may include:

  • infection;
  • pain;
  • sore throat;
  • headache;
  • nausea, vomiting;
  • gas, diarrhea, constipation; or.
  • stomach pain.

Is Redura taken empty stomach?

Redura can be taken either before or after food, although taking it before food is preferable. If you forget to take a dose at your usual time, you can generally take it when you remember.

Is Redura safe for my kidneys?

Redura can cause kidney problems.If you have blood in your urine. Diarrhea may be a sign of a new infection.

Is Redura safe during pregnancy?

Redura isn't usually recommended during pregnancy as there's no firm evidence it's safe. if you're pregnant, it's better to try to treat symptoms of acid reflux and heartburn without taking a medicine.

Is Redura safe to take while breastfeeding?

The SPC advises to avoid the use of rabeprazole during lactation.levels for both drugs are low, and in addition a large proportion of any of the drug ingested by the infant is likely to be destroyed by the acid in the stomach.

Does Redura work right away?

Redura starts doing its job within an hour of taking the first dose, you may not feel that your symptoms have improved for several days. This is because Redura has to “turn off” the proton pumps of the acid-producing cells in the stomach, and it is not able to turn off all proton pumps immediately.

How long Redura can be taken?

Redura is for short-term use only, usually 4 to 8 weeks. Your doctor may recommend a second course of treatment if you need additional healing time.

Is Redura good for gastritis?

Redura may good to treat: Reflux oesophagitis. Peptic ulcers. Chronic Gastritis.

Can Redura cause liver problems?

Redura therapy is associated with a low rate of transient and asymptomatic serum aminotransferase elevations and is a rare cause of clinically apparent liver injury.

Is Redura safe long term?

The drug is efficacious in gastro-esophageal reflux disease (GERD) and other acid-related diseases. Long-term use of Redura was confirmed to be safe in studies of two to five-year maintenance therapy for GERD.

What happens when you stop taking Redura?

Stopping the Redura suddenly could make your stomach produce a lot more acid, and make your symptoms return.you can stop taking rabeprazole without reducing the dose first. If you've taken Redura for a long time, speak to your doctor before you stop taking Redura.

Is Redura an antifungal?

Proton pump inhibitors, such as Redura act as agents with antifungal activity or reverse-acquired resistance to azoles.

Is Redura a controlled substance?

Redura 20 mg is not a controlled substance under the Controlled Substances Act (CSA).

What class of drug is Redura?

Redura is in a class of medications called proton-pump inhibitors.

Can you take Tylenol with Redura?

No interactions were found between Redura and Tylenol. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

How many Redura Can I take a day?

Adults can take Redura 20 milligrams (mg) once a day for up to 4 weeks. Your doctor may adjust your dose as needed. Children 12 years of age and older take Redura 20 mg once a day for up to 8 weeks. Your child's doctor may adjust the dose as needed.