Lucifate Suspension

Lucifate protects GI lining against peptic acid, pepsin and bile salts by binding with positively-charged proteins in exudates forming a viscous paste-like adhesive substance thus forming a protective coating.


Lucifate tablet is used for the treatment of acute, nonmalignant gastric and duodenal ulcers. Maintenance therapy to prevent the recurrence of duodenal ulcers.

Lucifate suspension is used for the short-term (up to 8 weeks) treatment of active duodenal ulcer.

Lucifate is also used to associated treatment for these conditions: Dyspepsia, Gastric Ulcer, Gastritis, Gastro-esophageal Reflux Disease (GERD), Healing, Mucositis, Peptic Ulcer, Stress Ulcers, Active Duodenal ulcer, Antiplatelet Therapy


Trade Name Lucifate
Generic Sucralfate
Sucralfate Other Names Sucralfat, Sucralfate, Sucralfato, Sucralfatum
Type Suspension
Formula C12H35Al9O55S8
Weight Average: 1558.67
Monoisotopic: 1557.6045961
Protein binding

Sucralfate is bound to plasma proteins, especially albumin and transferrin .

Therapeutic Class Chelating complex
Manufacturer Orion Biotech Pvt Ltd
Available Country India
Last Updated: June 23, 2021 at 9:00 am


Sucralfate Structure


Lucifate dosage

Adult: Usual dose 1 gm 4 times daily to be taken 1 hour before meals and at bed time. Maximum daily dose is 8 gm. Four to six weeks treatment is usually needed for ulcer healing but upto twelve weeks may be necessary in resistant cases. Antacids may be used as required for relief of pain, but should not be taken half an hour before or after Gastalfet.

Elderly: There are no special dosage requirements for elderly patients but as with all medicines the lowest effective dose should be used. 

children: Safety and efficacy in children have not been established

Side Effects

The incidence and severity of side effects from sucralfate are very low. Mild side effect like constipation has been reported in some patients.


The product should only be used with caution in patients with renal dysfunction


Concomitant use of sucralfate may reduce the bioavailability of certain drugs as has been observed in animal studies with tetracycline, phenytoin and cimetidine and in human studies with digoxin. Administration of sucralfate with any of these drugs should be separated by two hours. Since sucralfate may hinder warfarin absorption, caution should be exercised when these two drugs are used together.

Food Interaction

  • Take on an empty stomach. Take at least 1 hour before or 2 hours after meals.
  • Take separate from antacids. Take at least 30 minutes before or after antacids.

Volume of Distribution

This drug is absorbed in a very small quantity, and normally localizes to inflamed gastrointestinal lesions .

Half Life

The half-life is not known. In animals, the elimination half-life of the sucrose component of this drug is from 6-20 h .


Lucifate contains aluminum. The administration of sucralfate in non-dialyzed chronic renal failure patients warrants careful consideration from the treating physician as the excretion of absorbed aluminum may be decreased, causing possible aluminum toxicity .

In dialyzed patients diagnosed with chronic renal failure, aluminum toxicity related to sucralfate has been observed and reported. The daily amount of aluminum ingestion (including sucralfate) should be carefully examined before administering sucralfate in combination with other drugs also containing aluminum, including various antacids .

Pregnancy & Breastfeeding use

Although animal studies show no evidence of foetal malformation, safety in pregnant women has not been established and Lucifate should be used in pregnancy only if clearly needed.

It is not known whether this drug is excreted in human milk. Caution should be exercised when sucralfate is administered to nursing mothers.


There are no known contraindications

Acute Overdose

There is no experience in human with overdosage

Storage Condition

Store at 20-25° C.

Innovators Monograph

Lucifate contains Sucralfate see full prescribing information from innovator Monograph


What is Lucifate used for?

Lucifate is used short-term (up to 8 weeks) to treat an active duodenal ulcer. Lucifate works mainly in the lining of the stomach and is not highly absorbed into the body. This medicine adheres to ulcer sites and protects them from acids, enzymes, and bile salts.

Is Lucifate good for acid reflux?

Lucifate and omeprazole are used to treat ulcers and gastroesophageal reflux disease (GERD). Omeprazole is also used to treat Zollinger-Ellison syndrome, duodenitis, erosive esophagitis, heartburn, and H. pylori infection.

What are side effects of Lucifate?

Lucifate side effects are Constipation, dry mouth, upset stomach, gas, and nausea may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

What are the side effects of Lucifate?

Lucifate Side effects are include:

  • Back pain
  • Constipation
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Gas (flatulence)
  • Headache
  • Indigestion
  • Itching or skin rash
  • Nausea
  • Sleep problems (insomnia)
  • Spinning sensation (vertigo)
  • Stomach pain
  • Upset stomach
  • Vomiting

Is Lucifate bad for kidneys?

Aluminum accumulation and toxicity have been reported with the use of sucralfate in patients with compromised renal function. The risk of toxicity most likely represents a long-term complication of Lucifate use in this patient population.

Does Lucifate cure gastritis?

Lucifate is the primary agent for prophylaxis of stress gastritis. It has long been used as a means of decreasing the incidence of gastritis.

Can I drink water while taking Lucifate?

Take Lucifate by mouth with a glass of water. Follow the directions on the prescription label. This medicine works best if you take it on an empty stomach, 1 hour before meals. Take your doses at regular intervals.

Does Lucifate help with gas?

Lucifate administration was accompanied by the disappearance of heartburn, epigastric pain, epigastric distress, or epigastric burning in 42 of 59 occurrences, and by statistically significant reductions in bloating.

What is the best time to take Lucifate?

Take Lucifate on an empty stomach, 2 hours after or 1 hour before meals. Take Lucifate around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

What should not take with Lucifate?

Some antacids can make it harder for Lucifate to work in your stomach. Avoid taking an antacid within 30 minutes before or after taking Lucifate.

Can Lucifate cause loose stools?

Lucifate may cause constipation, diarrhea, nausea, and headache.

Can Lucifate cause frequent urination?

This medicine may affect your blood sugar levels. Check with your doctor right away if you have increased thirst or increased urination.

What color is urine when your kidneys are failing?

When kidneys are failing, the increased concentration and accumulation of substances in urine lead to a darker color which may be brown, red or purple. The color change is due to abnormal protein or sugar, high levels of red and white blood cells, and high numbers of tube-shaped particles called cellular casts.

Does Lucifate really work?

Lucifate has an average rating of 5.7 out of 10 from a total of 50 ratings for the treatment of Stomach Ulcer. 38% of those users who reviewed Lucifate reported a positive effect, while 30% reported a negative effect.

Does Lucifate coat the stomach?

Lucifate is used to treat and prevent duodenal ulcers and other conditions as determined by your doctor. It works by forming a barrier or coat over the ulcer. This protects the ulcer from the acid of the stomach, allowing it to heal.

Why Lucifate should not be used with antacids?

As the Lucifate is effective only in acid conditions, an antacid should not be taken 30 min before or after a dose. Lucifate interferes with absorption of several drugs, including ciprofloxacin, theophylline, digoxin, phenytoin and amitriptyline, possibly by binding due to its strong negative charge.