Scotia Tablet

Scotia is a synthetic, broad-spectrum antibacterial agent from the difluoroquinolone family. It has been reported to be more active in vitro than ciprofloxacin against some organisms, including staphylococci and Mycobacteria, and has a much longer plasma half-life (16 hours).

Scotia inhibits the supercoiling activity of DNA gyrase which is an enzyme essential for DNA replication thus promoting the breakage of DNA structures. It has activity against S. pneumoniae, S. aureus, H. influenzae, K. pneumoniae, M. catarrhalis and Mycobacterium spp.


Scotia is used for the treatment of the following infections due to susceptible microorganisms:

  • Upper and lower respiratory tract infections including sinusitis, acute exacerbation of chronic bronchitis, community and hospital acquired pneumonia.
  • Urinary tract infections including gonococcal and non-gonococcal urethritis, chancroid and other sexually transmitted diseases.
  • Skin and soft tissue infections.
  • Prophylactic use in different urological and ophthalmic operations.

Scotia is also used to associated treatment for these conditions: Acute Sinusitis, Chronic Obstructive Airways Disease Exacerbated, Community Acquired Pneumonia (CAP), Susceptible infections


Trade Name Scotia
Generic Sparfloxacin
Sparfloxacin Other Names Sparfloxacin
Type Tablet
Formula C19H22F2N4O3
Weight Average: 392.3998
Monoisotopic: 392.165997
Protein binding

Low plasma protein binding in serum at about 45%.

Therapeutic Class 4-Quinolone preparations
Manufacturer Orion Biotech Pvt Ltd
Available Country India
Last Updated: June 23, 2021 at 9:00 am


Sparfloxacin Structure


Scotia dosage

In patients with normal renal function the recommended daily dose is two tablets of Scotia 200 mg on first day as a loading dose, thereafter take one tablet of Scotia 200 mg every 24 hours for a total of 10 days of therapy. 

The recommended daily dose of Scotia in patients with renal impairment (Creatinine clearance < 30 ml/min) is two tablets of 200 mg taken on the first day as a loading dose. Thereafter, should be taken one tablet of 200 mg every 48 hours for total of 9 days of therapy.

Scotia can be taken with or without food.

Side Effects

Most of the adverse events were mild to moderate in severity and transient in nature. The most frequently reported events among the Scotia treated patients with the recommended dosage are: diarrhea, nausea, headache, dyspepsia, dizziness, insomnia, abdominal pain and QTc interval prolongation.


It should be used with caution in renal diseases, gastric ulcers and with concomitant use of NSAIDs. In renal failure of third degree severity (creatinine clearance < 30 ml/min) dosage modification is recommended 400 mg on 1st day, 200 mg on 2nd and 3rd day followed by 200 mg every 48 hours. Because fluoroquinolones have been associated with tendon rupture, Scotia should be discontinued at the first sign of tendon pain. Exposure to UV radiation during treatment should be avoided.


On concomitant use with Quinidine, Sotalol, Erythromycin, Astemizole, Terfenadine, vinca alkaloids there is increased risk of arrhythmia. Salts, oxides and hydroxides of Magnesium, Aluminium and Calcium decrease absorption of Scotia.

Half Life

Mean terminal elimination half-life of 20 hours (range 16-30 hours). Prolonged in patients with renal impairment (creatinine clearance <50 mL/min).

Pregnancy & Breastfeeding use

There are no adequate and well controlled studies in pregnant women. Scotia should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.


Scotia is contraindicated for individuals with a history of hypersensifivity and in achilles tend in its following the use of fluoroquinolone and in pregnancy and lactation. Scotia is contraindicated in patients with known QTc prolongation or in patients being treated concomitantly with medications known to produce an increase in the QTc interval and/or torsade depointes.

Special Warning

Use in children: Safety and effectiveness have not been established in patients below the age of 18 years.

Storage Condition

Store at temperature below 30° C.

Innovators Monograph

Scotia contains Sparfloxacin see full prescribing information from innovator Monograph


What is Scotia used for?

Scotia is an antibiotic in a class of drugs called fluoroquinolones. It fights bacteria in the body. Scotia is used to treat various types of bacterial infections.

How safe is Scotia?

Scotia passes into breast milk and may harm a nursing infant. It may affect bone development. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

What are the common side effects of Scotia?

The common side effects of  Scotia are include:

  • nausea
  • vomiting
  • diarrhea
  • constipation
  • headache
  • lightheadedness
  • drowsiness
  • ringing in the ears
  • increased sensitivity of the skin to sunlight
  • indigestion
  • dizziness
  • insomnia
  • abdominal pain
  • itching
  • changes in taste
  • gas
  • elevated blood pressure, and
  • heart rhythm disorders

Is Scotia safe during breastfeeding?

Scotia should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby. No studies have been done in animals, and no well-controlled studies have been done in pregnant women. Scotia should be given to a pregnant woman only if clearly needed.

Is Scotia safe during pregnancy?

Use of Scotia is acceptable in nursing mothers with monitoring of the infant for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis.

How should I take Scotia?

Take Scotia exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
Take each dose with a full glass of water (8 ounces). Drink several extra glasses of fluid each day to prevent the formation of Scotia crystals in your urine.

How do I take Scotia?

Take each dose with a full glass of water (8 ounces). Drink several extra glasses of fluid each day to prevent the formation of Scotia crystals in your urine.Scotia may be taken with or without food. Take Scotia at evenly spaced intervals.

How long does Scotia take to work?

You will start to feel better in 2 to 3 days after taking/using Scotia.

What happens if I miss a dose of Scotia?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.

What happens if I overdose?

Seek emergency medical attention.
The most common symptom of a Scotia overdose is irregular or slow heartbeats.

Can I drive after taking Scotia?

Do not drive a car or work on dangerous machines until you know how Scotia will affect you. plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen.

Can Scotia treat staphylococcus?

In vitro tests show that the combination of Scotia and rifampin is antagonistic against Staphylococcus aureus.

Is Scotia an antibiotic?

Scotia is an antibiotic in a class of drugs called fluoroquinolones. It fights bacteria in the body. Scotia is used to treat various types of bacterial infections.