Refractory Peripheral T-cell Lymphoma Unspecified
What is Refractory Peripheral T-cell Lymphoma Unspecified?
Refractory peripheral T-cell lymphoma (RPTCL) is a rare type of non-Hodgkin lymphoma (NHL). It is a subset of peripheral T-cell lymphomas (PTCLs); these are a group of cancers of the white blood cells, or lymphocytes, that originate from mature T cells. RPTCL is a type of T-cell lymphoma that is resistant to other treatments, and it is considered a higher grade lymphoma.
RPTCLs are typically extra-nodal, meaning it can occur in tissues other than lymph nodes. It is not well-understood and difficult to diagnose and treat. Symptoms vary depending on the site of the tumor, but they often include fever, night sweats, and weight loss.
Cause
RPTCL is caused by a mutation in the T cells of the immune system. These cells travel through the body and act as the body’s defense against foreign invaders. When the cells become mutated, they can become cancerous, presenting itself in the form of RPTCL. RPTCL is usually treated with chemotherapy, radiation, and/or targeted therapies.
Diagnosis
RPTCL is typically diagnosed by a combination of physical examination, laboratory tests, imaging, and biopsy. Imaging tests such as computed tomography (CT) scans or magnetic resonance imaging (MRI) may be used to assess the extent of the cancer. A biopsy is often needed to confirm the diagnosis and identify the type of lymphoma.
Treatment
Treatment for RPTCL may include chemotherapy, radiation therapy, immunotherapy, or targeted therapy. In some cases, a combination of therapies may be used. Treatment may also include supportive care, such as pain and symptom management.
Signs and Symptoms
- Fever
- Night Sweats
- Weight Loss
- Swollen Lymph Nodes
- Fatigue
- Pain or Discomfort in the Abdomen