Locally advanced gastrointestinal origin Progressive Neuroendocrine Tumors
Overview of Locally Advanced Gastrointestinal Origin Progressive Neuroendocrine Tumors (LAGIT NETs)
Locally Advanced Gastrointestinal Origin Progressive Neuroendocrine Tumors (LAGIT NETs) are a class of malignant tumors, with neuroendocrine properties, that arise from the tissues of the gastrointestinal tract. These tumors, although rare, can be life-threatening when they metastasize or spread to other parts of the body.
The World Health Organization (WHO) classification of LAGIT NETs includes five specific types:
- Carcinoid tumor
- Gastroenteropancreatic neuroendocrine carcinoma
- Gastrointestinal stromal tumor
- Pancreatic endocrine tumor
- Unknown primary site
Carcinoid is the most common form of LAGIT NET. It is a slow-growing tumor that typically arises in the small intestine. Gastroenteropancreatic neuroendocrine carcinoma is a much more aggressive type of NET that usually arises in the pancreas and can spread to other organs. Gastrointestinal stromal tumors are usually slow growing and can be found in the stomach, small intestine, or large intestine. Pancreatic endocrine tumors typically arise in the pancreas and can be slow or fast growing. These tumors can be difficult to diagnose, as they can be confused with non-cancerous diseases such as irritable bowel syndrome.
Treatment options for LAGIT NETs depend on the type, size, and extent of the tumor. Surgery is typically the treatment of choice for localized tumors. Other treatments such as chemotherapy, radiation, and targeted therapies may also be used for individuals with metastatic disease. In some cases, a combination of these treatments may be recommended.
It is important to consult with your doctor if you have any of the symptoms mentioned above. Early diagnosis and treatment can often lead to a better outcome. If you have been diagnosed with a NET, it is important to discuss your treatment options with your healthcare team in order to make the best decision for your health.