Castleman's Disease

What is Castleman's Disease?

Castleman's Disease, also known as a hyaline-vascular lymphoma, is a rare disorder characterized by enlargement of the lymph nodes and other organs in the body. In some people, it can cause life-threatening complications. It is caused by a specific type of aberrant immune response and is believed to arise from a combination of genetic and environmental factors. Currently, there is no known cure but treatments may help control symptoms.

Symptoms of Castleman's Disease

The most common symptoms of Castleman's Disease are enlargement of the lymph nodes and organs like the liver and spleen, fevers, night sweats, weight loss, fatigue, and, in some cases, difficulty with breathing. In severe cases, complications can include anemia, leukopenia, thrombocytopenia, and hypercalcemia.

Diagnosis of Castleman's Disease

In order to diagnose Castleman's Disease, doctors may use a variety of techniques, including imaging studies, biopsies, and blood tests. Imaging studies such as CT scans and MRI can provide useful information about the location and size of any affected lymph nodes or organs. Biopsy of the affected tissue can also provide useful information for diagnosis. Blood tests can help determine the type of abnormality present.

Treatment of Castleman's Disease

Currently, there is no known cure for Castleman's Disease, however treatments are available to help control symptoms and reduce the risk of complications. Treatment options may include:

  • Corticosteroids
  • Immunomodulatory drugs
  • Targeted therapies
  • Radiation or chemotherapy
  • Surgery to remove affected lymph nodes or organs