Autosomal Dominant Polycystic Kidney Disease （ADPKD)
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is an inherited condition in which a person is born with multiple fluid-filled sacs (cysts) in their kidneys. These cysts grow and multiply over time, eventually leading to progressive and irreversible damage to the kidneys, as well as other organ systems. ADPKD is the most common inherited kidney disease, affecting approximately one in every 500 to 1000 people, and is the fourth leading cause of end-stage kidney failure.
Symptoms of ADPKD
ADPKD can cause a wide range of symptoms including:
- High blood pressure
- Headaches
- Back pain
- Abdominal pain
- Blood in the urine
- Frequent urination
- Poor appetite
- Fatigue
- Swelling in the hands, feet, and/or face
- Kidney stones
Diagnosis and Treatment
ADPKD is usually diagnosed based on a combination of family history, physical exams, imaging studies (such as ultrasound), and urine tests. Treatment for ADPKD is focused on managing symptoms and slowing the progression of the disease. This may include medications to lower blood pressure, pain relief, and lifestyle changes such as eating a healthy diet, exercising regularly, and avoiding smoking. In more severe cases, medical procedures such as cyst aspiration, embolization, or kidney transplantation may be necessary.
Living with ADPKD
ADPKD is a chronic, progressive condition, meaning that it will get worse over time. While there is no cure, ongoing medical care and lifestyle changes can help to manage symptoms and prolong an active, healthy quality of life. It is important to have regular check ups with a doctor, undertake recommended screenings, and follow any medical advice or treatments to help manage the disease.