Vercef Af

Vercef Af Uses, Dosage, Side Effects, Food Interaction and all others data.

Vercef Af, a second generation cephalosporin, demonstrates the bactericidal action by inhibiting cell wall synthesis. It is active against the following organisms In Vitro:

Aerobes, Gram-positive: Streptococcus pneumoniae, Streptococcus pyogenes (Group A beta-haemolytic streptococci) and Staphylococci.

Aerobes, Gram-negative: Moraxella catarrhalis, Haemophilus influenzae, Escherichia coli, Proteus mirabilis, Klebsiella sp.,Citobacter diversus and Neisseria gonorrhoeae.Anaerobes: Propionibacteria acnes, Bacteroides sp. (excluding Bacteroides fragilis), Peptococci and Peptostreptococcus sp.

Vercef Af is a second generation cephalosporin antibiotic with a spectrum resembling first-generation cephalosporins. In vitro tests demonstrate that the bactericidal action of the cephalosporins results from inhibition of cell-wall synthesis. As indicated by in vitro and in vivo clinical studies, cefaclor was shown to be effective against most strains of Gram positive aerobes - Staphylococci (including coagulase-positive, coagulase-negative, and penicillinase-producing strains), Streptococcus pneumoniae, Streptococcus pyogenes (group A ß-hemolytic streptococci), as well as Gram-negative aerobes - Escherichia coli, Haemophilus influenzae (including ß-lactamase-producing ampicillin-resistant strains), Klebsiella sp, and Proteus mirabilis.

Trade Name Vercef Af
Availability Prescription only
Generic Cefaclor
Cefaclor Other Names Cefaclor, Céfaclor, Cefaclorum, Céfeaclor, Cephaclor
Related Drugs amoxicillin, prednisone, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin
Type Tablet
Formula C15H14ClN3O4S
Weight Average: 367.807
Monoisotopic: 367.039354348
Protein binding


Groups Approved
Therapeutic Class Second generation Cephalosporins
Manufacturer Ranbaxy Laboratories (sun Pharma)
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Vercef Af
Vercef Af


Oticlor is used for the treatment of the following infections:

Otitis media

Lower respiratory tract infections, including pneumonia, bronchitis and acute exacerbation of chronic bronchitis

Upper respiratory tract infections, including pharyngitis and tonsillitis

Urinary tract infections, including pyelonephritis and cystitis

Skin and soft tissue infections


Vercef Af is also used to associated treatment for these conditions: Acute Exacerbation of Chronic Bronchitis caused by Streptococcus Pneumoniae, Acute Exacerbations of Chronic Bronchitis caused by Haemophilus Influenza, Acute Exacerbations of Chronic Bronchitis caused by Moraxella catarrhalis, Bacterial Infections, Bacterial Urinary Tract Infections, Lower respiratory tract infection bacterial, Staphylococcal Skin Infections, Streptococcal Pharyngitis, Streptococcal tonsillitis, Bacterial otitis media, Streptococcus pyogenes skin infection, Susceptible Bacterial Infections

How Vercef Af works

Vercef Af, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. It is possible that cefaclor interferes with an autolysin inhibitor.


Vercef Af dosage

Vercef Af Monohydrate is administered orally.

Children: The usual recommended dosage for children is 20 mg/kg/day in divided doses every 8 hours. The dose of Oticlor suspension and paediatric drops for children is given in the following:

Age Vercef Af Monohydrate suspension , Vercef Af MonohydratePaediatric Drops

1 month - 1 year 2.5 ml t.i.d. 0.625 ml t.i.d

1 year - 5 year 5 ml t.i.d. 1.25 ml t.i.d

over 5 years 10 ml t.i.d 2.5 ml t.i.d

In more serious infections, such as otitis media, or those caused by less susceptible organisms, 40 mg/kg/day is recommended, with a maximum dosage of 1 gm/day. Safety and efficacy have not been established for use in infants aged less than 1 month.

Adults: The usual adult dose is 250 mg every 8 hours. For bronchitis, the dosage is 250 mg administered 3 times daily. A dosage of 250 mg administered 3 times daily for 10 days is recommended for sinusitis. For more severe infections, such as pneumonia, or those caused by less susceptible organisms, dose may be doubled.

Vercef Af may be administered safely in the presence of impaired renal function. Under such conditions, dosage is usually unchanged.

Side Effects

Most adverse effects reported with Vercef Af are similar to those reported with other oral cephalosporins. The most frequent adverse effects reported include gastrointestinal effects (nausea, vomiting, diarrhea) headache and rash. Rarely, Serum sickness-like reactions consisting of erythema multiforme, urticaria accompanied by arthritis, arthralgia, irritability and fever have been reported.


Symptoms of overdose include diarrhea, nausea, stomach upset, and vomiting.


Vercef Af should be administered with caution in the presence of markedly impaired renal function. Dosage adjustments for patients with moderate or severe renal impairment are not usually required.


There have been reports of increased anticoagulant effect when Vercef Af and oral anticoagulants were administered concomitantly. The renal excretion of Vercef Af is inhibited by probenecid.

Direction for reconstitution of suspension

For 100 ml suspension: Add 60 ml (12 measuring spoonful) of boiled and cooled water to the dry powder of the bottle. For ease of preparation, add water to the bottle in two proportions. Shake well after each addition until all the powder is in suspension.

Paediatric drops: Add 10 ml (2 measuring spoonful) of boiled and cooled water to the bottle and shake vigorously.

Note: Shake the suspension and paediatric drop well before each use. Keep the bottle tightly closed. The reconstituted suspension should be stored in a cool and dry place, preferably in refrigerator. The made up suspension can be used within 7 days if it is stored at room temperature and 14 days if it is kept in refrigerator.

Food Interaction

  • Take with or without food.

Elimination Route

Well absorbed after oral administration, independent of food intake.

Half Life

0.6-0.9 hour

Elimination Route

Approximately 60% to 85% of the drug is excreted unchanged in the urine within 8 hours, the greater portion being excreted within the first 2 hours.

Pregnancy & Breastfeeding use

Pregnancy: Animal studies have shown no evidence of impaired fertility or teratogenicity. However, since there are no adequate or well-controlled studies in pregnant women, caution should be exercised when prescribing for the pregnant women.Lactation: Small amount of Vercef Af have been detected in breast milk following administration of single 500 mg dose. As the effect on nursing infants is not known, caution should be exercised when Vercef Af is administered to a nursing woman.


Vercef Af is contraindicated in patients with known allergy to the Cephalosporin group of antibiotics.

Acute Overdose

The symptoms following an overdose of Vercef Af may include nausea, vomiting, epigastric distress, and diarrhea. The severity of the epigastric distress and diarrhea is dose related.

Unless 5 times the normal dose of Vercef Af has been ingested, gastrointestinal lavage will not be necessary.

Storage Condition

Store in a cool and dry place. Protect from light.

Innovators Monograph

You find simplified version here Vercef Af

Vercef Af contains Cefaclor see full prescribing information from innovator Vercef Af Monograph, Vercef Af MSDS, Vercef Af FDA label


What is Vercef Af used for?

Vercef Af is a second-generation cephalosporin antibiotic used to treat certain bacterial infections such as pneumonia and infections of the ear, lung, skin,tonsils, throat, and urinary tract. 

How safe is Vercef Af?

Vercef Af was found to be a safe and efficacious drug in the treatment of bacterial respiratory tract infections amongst Pakistani children.

How does Vercef Af work?

Vercef Af works by killing or stopping the growth of bacteria (bugs) and gets rid of the infection.

What are the common side effects of Vercef Af?

Common side effects of Vercef Af are include:

  • diarrhea.
  • nausea.
  • vomiting.
  • stomach pain.
  • headache.
  • genital itching.

Is Vercef Af safe during pregnancy?

Research in animals has not shown a risk to the fetus when the mother takes the drug.This medicine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Is Vercef Af safe during breastfeeding?

Vercef Af is acceptable in nursing mothers.

Can I drink alcohol with Vercef Af?

You shouldn't drink alcohol during treatment with this medication. Talk to your doctor if this may be a problem.

Can I drive after taking Vercef Af?

Vercef Af may cause dizziness or drowsiness in some people. If you have any of these symptoms, do not drive, operate machinery or do anything else that could be dangerous.

When should be taken of Vercef Af?

The capsule and liquid are usually taken with or without. The long-acting tablet is usually taken within 1 hour of eating a meal every 12 hours (twice a day) for 7 to 10 days . Take Vercef Af at around the same times every day.

Can I take Vercef Af on an empty stomach?

It does not matter if Vercef Af is given with food or on an empty stomach. It may be given with food if stomach upsets occur. It is important to give the full course of treatment.

How often can I take Vercef Af?

Can you take Vercef Af every 8 or 12 hours.

How long does Vercef Af last for?

Vercef Af will have been made up by the pharmacy and lasts for 14 days, so check the expiry date on the bottle and do not use it after this date.

How long can I take Vercef Af for?

Your doctor will advise you how long to take cefaclor for usually 5 to 7 days, but can be up to 10 days.

What happens if I miss a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Who should not take Vercef Af?

You should not use this Vercef Af if you are allergic to cefoxitin or to similar antibiotics, such as cefdinir , cefprozil , cefuroxime , cephalexin , and others.

What happens if I overdose?

Seek emergency medical attention. Overdose symptoms may include nausea, vomiting, stomach pain, and diarrhea.

What happen If I suddenly stop taking Vercef Af ?

If you stop taking this drug suddenly, your infection may not be treated. This could cause the bacteria to become resistant to the drug. That means that cefaclor or other antibiotics won't work for you to treat future infections caused by these bacteria.

Is Vercef Af safe for children?

Vercef Af appears to be a safe, well tolerated and effective antimicrobial agent in children.

*** Taking medicines without doctor's advice can cause long-term problems.