Rifapentin

Rifapentin Uses, Dosage, Side Effects, Food Interaction and all others data.

Rifapentin is an antibiotic drug used in the treatment of tuberculosis. It inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.

Rifapentin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifampin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.

Trade Name Rifapentin
Availability Prescription only
Generic Rifapentine
Rifapentine Other Names Cyclopentylrifampicin, Rifapentin, Rifapentine
Related Drugs ciprofloxacin, levofloxacin, Levaquin, rifampin, isoniazid, pyrazinamide, Rifadin, Priftin, Nydrazid
Type
Formula C47H64N4O12
Weight Average: 877.0307
Monoisotopic: 876.452073532
Protein binding

97.7% (bound to plasma proteins)

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Rifapentin
Rifapentin

Uses

Rifapentin is an antibiotic agent used in the treatment of pulmonary tuberculosis.

For the treatment of pulmonary tuberculosis.

Rifapentin is also used to associated treatment for these conditions: Active Tuberculosis, Late phase Tuberculosis

How Rifapentin works

Rifapentin has shown higher bacteriostatic and bactericidal activities especially against intracellular bacteria growing in human monocyte-derived macrophages. Rifapentin inhibits DNA-dependent RNA polymerase in susceptible strains of M. tuberculosis. Rifapentin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.

Food Interaction

  • Take with food. Taking rifapentine with food increases its bioavailability and reduces gastrointestinal upset. Rifapentin tablets can be crushed and mixed with semisolid food if necessary.

Rifapentin Disease Interaction

Major: colitis, liver disease

Volume of Distribution

  • 70.2 ± 9.1 L

Elimination Route

Rapidly and well absorbed from the gastrointestinal tract.

Clearance

  • Apparent Oral cl=2.51 +/- 0.14 L/h [Male tuberculosis patients who received 600 mg rifapentine in combination with isoniazid, pyrazinamide and ethambutol]
  • Apparent Oral cl=1.69 +/- 0.41 L/h [Female tuberculosis patients who received 600 mg rifapentine in combination with isoniazid, pyrazinamide and ethambutol]

Elimination Route

Following a single 600 mg oral dose of radiolabeled rifapentine to healthy volunteers (n=4), 87% of the total 14C rifapentine was recovered in the urine (17%) and feces (70%).

Innovators Monograph

You find simplified version here Rifapentin

*** Taking medicines without doctor's advice can cause long-term problems.
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