Nydrazid

Nydrazid Uses, Dosage, Side Effects, Food Interaction and all others data.

Nydrazid inhibits the synthesis of mycoloic acids in susceptible bacteria which results in loss of acid-fastness and disruption of bacterial cell wall. At therapeutic levels, it is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms.

Nydrazid is a bactericidal agent active against organisms of the genus Mycobacterium, specifically M. tuberculosis, M. bovis and M. kansasii. It is a highly specific agent, ineffective against other microorganisms. Nydrazid is bactericidal when mycobacteria grow rapidly and bacteriostatic when they grow slowly.

Trade Name Nydrazid
Availability Prescription only
Generic Isoniazid
Isoniazid Other Names 4-pyridinecarbohydrazide, Isoniazid, Isoniazida, Isonicotinic acid hydrazide, Isonicotinic hydrazide, Isonicotinohydrazide, Isonicotinoylhydrazide, Isonicotinsäurehydrazid, Isonicotinylhydrazine
Related Drugs ciprofloxacin, levofloxacin, Levaquin, rifampin, pyrazinamide, rifabutin, bcg, rifapentine, Rifadin, Priftin
Weight 50mg/5ml, 100mg, 300mg,
Type Oral syrup, oral tablet
Formula C6H7N3O
Weight Average: 137.1393
Monoisotopic: 137.058911861
Protein binding

Very low (0-10%)

Groups Approved, Investigational
Therapeutic Class Anti-Tubercular Chemotherapeutics
Manufacturer
Available Country United States,
Last Updated: September 19, 2023 at 7:00 am
Nydrazid
Nydrazid

Uses

Nydrazid is used for the treatment of all forms of tuberculosis in which organisms are susceptible.

Nydrazid is also used to associated treatment for these conditions: Active Tuberculosis, Mycobacterium kansasii infection, Late phase Tuberculosis

How Nydrazid works

Nydrazid is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex. Once activated, isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. At therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms. Specifically isoniazid inhibits InhA, the enoyl reductase from Mycobacterium tuberculosis, by forming a covalent adduct with the NAD cofactor. It is the INH-NAD adduct that acts as a slow, tight-binding competitive inhibitor of InhA.

Dosage

Nydrazid dosage

Adult:

  • Active tuberculosis: 5 mg/kg/day. Max: 300 mg/day or 15 mg/kg up to 900 mg/day, 2 or 3 times wkly.
  • Latent tuberculosis: 300 mg/day for 6 mth. Nontuberculous mycobacterial infections 5 mg/kg/day for at least 12 mth of culture-negative sputum. Max: 300 mg/day.

Child:10-15 mg/kg/day, max 300 mg/day q 12-24 hourlyWith directly observed biweekly therapy, dosage is 20-30 mg/kg, max 900 mg/dose twice weekly

Side Effects

Peripheral neuropathy (dose-related incidence, 10-20% incidence with 10 mg/kg/d), Loss of appetite, Nausea, Vomiting, Stomach pain, Weakness 1-10%, Dizziness, Slurred speech, Lethargy, Progressive liver damage (increases with age; 2.3% in pts > 50 yo), Hyperreflexia, Agranulocytosis, Anemia, Megaloblastic anemia, Thrombocytopenia, Systemic lupus erythematosus, Seizure

Toxicity

LD50 100 mg/kg (Human, oral). Adverse reactions include rash, abnormal liver function tests, hepatitis, peripheral neuropathy, mild central nervous system (CNS) effects. In vivo, Nydrazid reacts with pyridoxal to form a hydrazone, and thus inhibits generation of pyridoxal phosphate. Nydrazid also combines with pyridoxal phosphate; high doses interfere with the coenzyme function of the latter.

Precaution

Renal or hepatic impairment; convulsive disorders; history of psychosis; patients at risk of neuropathy or pyridoxine deficiency eg, diabetic, alcoholic, malnourished, uraemic, infected with HIV. Careful monitoring of hepatic function is necessary for black and hispanic women. Check hepatic function before and during treatment. Pregnancy and lactation.

Interaction

Inhibit the hepatic metabolism of antiepileptics (e.g. carbamazepine, ethosuximide, primidone, phenytoin), benzodiazepines (e.g. diazepam, triazolam), chlorzoxazone, theophylline, disulfiram, sometimes leading to increased toxicity. Increased metabolism of enflurane, resulting in potentially nephrotoxic levels of fluoride. Increased concentrations and enhanced effects or toxicity of clofazimine, cycloserine and warfarin. Reduced absorption with Al-containing antacids. Increased risk of peripheral neuropathy with zalcitabine and stavudine.

Food Interaction

  • Administer vitamin supplements. Vitamin B6 (pyridoxine) should be given with isoniazid to prevent deficiency.
  • Avoid alcohol. Avoid drinking alcoholic beverages such as unpasteurized beer; unless approved by your physician, as they may contain tyramine. Consuming alcohol may also increase the risk of isoniazid induced hepatitis and neuropathy.
  • Avoid chocolate. Chocolate contains caffeine, which should be limited during isoniazid therapy.
  • Avoid histamine-containing foods and supplements. Histamine-containing foods (e.g., skipjack, tuna, other tropical fish) can cause headaches, sweating, palpitations, flushing, and hypotension.
  • Avoid tyramine-containing foods and supplements. Tyramine-containing foods include cheese, red wine, fava beans, pickled food, cured food, and alcoholic beverages.
  • Limit caffeine intake.
  • Take on an empty stomach. Take at least 1 hour before or 2 hours after meals.
  • Take separate from antacids. Taking this medication with antacids can reduce absorption.

[Moderate] ADJUST DOSING INTERVAL: Administration with food significantly reduces isoniazid absorption, increasing the risk of therapeutic failure or resistance.

The mechanism is unknown.



GENERALLY AVOID: Concomitant administration of isoniazid with foods containing tyramine or histamine may decrease the metabolism of tyramine and histamine, increasing the risk of symptoms relating to tyramine- and

The proposed mechanism is isoniazid-mediated inhibition of monoamine oxidase (MAO) and diamine oxidase (DAO), enzymes responsible for the metabolism of tyramine and histamine, respectively.



MANAGEMENT: Nydrazid should be administered on an empty stomach, one hour before or two hours after meals.

Patients should be advised to avoid foods containing tyramine (e.g., aged cheese, cured meats such as sausages and salami, fava beans, sauerkraut, soy sauce, beer, or red wine) or histamine (e.g., skipjack, tuna, mackerel, salmon) during treatment with isoniazid.

Corticosteroids and antihistamines may be considered if histamine intoxication is suspected.

Nydrazid Alcohol interaction

[Moderate] GENERALLY AVOID:

Alcoholic patients have been shown to have a higher incidence of isoniazid-induced hepatotoxicity.

The mechanism has not been established.



Patients should be counseled to avoid the combination of alcohol and isoniazid and clinicians should be aware of the risk for increased hepatotoxicity in these patients.

Elimination Route

Readily absorbed following oral administration; however, may undergo significant first pass metabolism. Absorption and bioavailability are reduced when isoniazid is administered with food.

Half Life

Fast acetylators: 0.5 to 1.6 hours. Slow acetylators: 2 to 5 hours.

Elimination Route

From 50 to 70 percent of a dose of isoniazid is excreted in the urine within 24 hours.

Pregnancy & Breastfeeding use

Pregnancy Category C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Lactation: distributed into milk but safe for nursing infants

Contraindication

Acute liver disease or history of hepatic damage during INH therapy; hypersensitivity.

Innovators Monograph

You find simplified version here Nydrazid

Nydrazid contains Isoniazid see full prescribing information from innovator Nydrazid Monograph, Nydrazid MSDS, Nydrazid FDA label

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000002
http://classyfire.wishartlab.com/tax_nodes/C0000089
http://classyfire.wishartlab.com/tax_nodes/C0001322
http://classyfire.wishartlab.com/tax_nodes/C0001322
http://classyfire.wishartlab.com/tax_nodes/C0004144
http://classyfire.wishartlab.com/tax_nodes/C0001165
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000323
http://classyfire.wishartlab.com/tax_nodes/C0000278
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:6030
http://metacyc.org/META/new-image?type=COMPOUND&object=ISONIAZIDE
http://www.hmdb.ca/metabolites/HMDB0015086
http://www.genome.jp/dbget-bin/www_bget?drug:D00346
http://www.genome.jp/dbget-bin/www_bget?cpd:C07054
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3767
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506039
https://www.chemspider.com/Chemical-Structure.3635.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50336507
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=6038
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=6030
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL64
https://zinc.docking.org/substances/ZINC000000001590
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000011
http://www.pharmgkb.org/drug/PA450112
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/NIZ
http://www.rxlist.com/cgi/generic2/isoniaz.htm
https://www.drugs.com/cdi/isoniazid.html
https://en.wikipedia.org/wiki/Isoniazid
*** Taking medicines without doctor's advice can cause long-term problems.
Share