Prid Ds

Prid Ds Tablet

Prid Ds is an 8-aminoquinoline antimalarial which eliminates the exoerythrocytic forms of malarial parasite Plasmodium vivax, Plasmodium ovale and Plasmodium falciparum by disrupting mitochondria and binding to DNA.

Prid Ds's mechanism of action is not well understood. It may be acting by generating reactive oxygen species or by interfering with the electron transport in the parasite. Also, although its mechanism of action is unclear, primaquine may bind to and alter the properties of protozoal DNA.

Uses

Prid Ds phosphate is used for the radical cure (prevention of relapse) of vivax malaria.

Prid Ds is also used to associated treatment for these conditions: Malaria caused by Plasmodium ovale, Malaria caused by plasmodium vivax, Plasmodium Infections, Pneumocystis Jirovecii Pneumonia

Prid Ds

Trade Name Prid Ds
Generic Primaquine
Primaquine Other Names Primachin, Primachina, Primachinum, Primaquin, Primaquina, Primaquine, Primaquinum
Type Tablet
Formula C15H21N3O
Weight Average: 259.3467
Monoisotopic: 259.168462309
Therapeutic Class Anti-malarial drugs
Manufacturer Bennet Pharmaceuticals Ltd
Available Country India
Last Updated: June 23, 2021 at 9:10 am

Structure

Prid Ds
Primaquine Structure

Dosage

Prid Ds dosage

Prid Ds phosphate is recommended only for the radical cure of vivax malaria, the prevention of relapse in vivax malaria, or following the termination of chloroquine phosphate suppressive therapy in an area where vivax malaria is endemic. Patients suffering from an attack of vivax malaria or having parasitized red blood cells should receive a course of chloroquine phosphate, which quickly destroys the erythrocytic parasites and terminates the paroxysm. Prid Ds phosphate should be administered concurrently in order to eradicate the exoerythrocytic parasites in a dosage of 1 tablet (equivalent to 15 mg base) daily for 14 days.

Should be taken with food. Take with meals to avoid GI discomfort.

Side Effects

Abdominal pain, gastric distress, nausea, vomiting; methaemoglobinaemia, haemolytic anaemia (in patients with G6PD deficiency), mild anaemia, leucocytosis; HTN, cardiac arrhythmias, prolonged QT interval on ECG, accommodation disturbance. Rarely, leucopenia, agranulocytosis.

Precaution

Patient with G6PD deficiency, NADH methaemoglobin reductase deficiency. Childn. Pregnancy and lactation.

Interaction

Enhanced effect with other drugs that prolong the QT interval.

Food Interaction

  • Take with food. Food decreases irritation.

Half Life

3.7-7.4 hours

Pregnancy & Breastfeeding use

Pregnancy Category C. Safe usage of Prid Ds Phosphate in pregnancy has not been established. Prid Ds is contraindicated in pregnant women. Even if a pregnant woman is G6PD normal, the fetus may not be. Animal data show toxicity to reproduction.

Lactation: It is not known whether Prid Ds is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Prid Ds, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Contraindication

Acutely ill patients suffering from systemic disease manifested by tendency to develop granulocytopenia (e.g. rheumatoid arthritis, lupus erythematosus). Concurrent use with other potentially haemolytic drugs or depressants of myeloid elements of the bone marrow. Concomitant admin with mepacrine.

Acute Overdose

Symptoms of overdosage of Prid Ds phosphate include abdominal cramps, vomiting, burning epigastric distress, central nervous system and cardiovascular disturbances, including cardiac arrhythmia and QT interval prolongation, cyanosis, methemoglobinemia, moderate leukocytosis or leukopenia, and anemia. The most striking symptoms are granulocytopenia and acute hemolytic anemia in G6PD deficient patients. Acute hemolysis occurs, but patients recover completely if the dosage is discontinued.

Storage Condition

Store at 25° C. Protect from light.

Innovators Monograph

Prid Ds contains Primaquine see full prescribing information from innovator Monograph