Leukine

Leukine Uses, Dosage, Side Effects, Food Interaction and all others data.

Leukine is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.

Leukine is used in the treatment of bone marrow transplant recipients or those exposed to chemotherapy an recovering from acut myelogenous leukemia, Leukine or GM-CSF is a hematopoietic growth factor which stimulates the survival, clonal expansion (proliferation) and differentiation of hematopoietic progenitor cells. GM-CSF is also capable of activating mature granulocytes and macrophages. After a bone marrow transplant or chemotherapy, patients have a reduced capacity to produce red and white blood cells. Supplementing them with external sources of GM-CSF helps bring the level of neutrophils back to normal so that they can better fight infections.

Table Of contents

• Leukine
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Leukine
Availability	Prescription only
Generic	Sargramostim
Sargramostim Other Names	rGM-CSF, rHu GM-CSF, Sargramostim
Related Drugs	fluconazole, Diflucan, cisplatin, Neulasta, Promacta, filgrastim, Zarxio, Neupogen, pegfilgrastim, eltrombopag
Weight	250mcg,
Type	Injectable powder for injection
Formula	C639H1006N168O196S8
Weight	14434.5 Da
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	United States,
Last Updated:	September 19, 2023 at 7:00 am

Uses

Leukine is a modified form of recombinant human granulocyte-macrophage colony stimulating factor used to increase immune cell production after myelosuppressive therapy or bone marrow transplant.

For the treatment of cancer and bone marrow transplant

Leukine is also used to associated treatment for these conditions: Bone Marrow Suppression, Delayed engraftment, Graft Failure, Neutropenia, Mobilization of hematopoietic progenitor cells into peripheral blood for collection by leukapheresis therapy

How Leukine works

Leukine binds to the Granulocyte-macrophage colony stimulating factor receptor (GM-CSF-R-alpha or CSF2R) which stimulates a JAK2 STAT1/STAT3 signal transduction pathway. This leads to the production of hemopoietic cells and neutrophils

Food Interaction

No interactions found.

Leukine Drug Interaction

Unknown: amphotericin b lipid complex, isotretinoin, tocilizumab, corticotropin, alteplase, loxapine, fluticasone / salmeterol, theophylline, ketotifen ophthalmic, aluminum hydroxide, testosterone, umeclidinium / vilanterol, dolasetron, hydralazine, mesalamine, ethinyl estradiol / norethindrone, darbepoetin alfa, leflunomide, donepezil, benazepril

Leukine Disease Interaction

Major: arrhythmia, fluid retention, hepatic dysfunction, leukocytosis, myeloid tumors, prematurity, renal dysfunction, respiratory symptoms

Clearance

• 420 mL/min/m2 [Normal people with liquid LEUKINE (IV)]
• 431 mL/min/m2 [Normal people with lyophilized LEUKINE (IV)]
• 549 mL/min/m2 [Normal people with liquid LEUKINE (SC)]
• 529 mL/min/m2 [Normal people with lyophilized LEUKINE (SC)]

Innovators Monograph

You find simplified version here Leukine