Wytensin
Wytensin Uses, Dosage, Side Effects, Food Interaction and all others data.
An alpha-2 selective adrenergic agonist used as an antihypertensive agent. [PubChem]
Wytensin, a centrally acting α-2 adrenergic agonist, is indicated for treatment of hypertension.
| Trade Name | Wytensin |
| Availability | Prescription only |
| Generic | Guanabenz |
| Guanabenz Other Names | Guanabenz, Guanabenzo, Guanabenzum |
| Related Drugs | amlodipine, lisinopril, metoprolol, losartan, furosemide, hydrochlorothiazide |
| Type | Oral |
| Formula | C8H8Cl2N4 |
| Weight | Average: 231.082 Monoisotopic: 230.01260169 |
| Protein binding | 90% |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States, |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Wytensin is an alpha-2 adrenergic agonist used to treat hypertension.
For management of High blood pressure
How Wytensin works
Wytensin's antihypertensive effect is thought to be due to central alpha-adrenergic stimulation, which results in a decreased sympathetic outflow to the heart, kidneys, and peripheral vasculature in addition to a decreased systolic and diastolic blood pressure and a slight slowing of pulse rate. Chronic administration of guanabenz also causes a decrease in peripheral vascular resistance.
Toxicity
Excessive contraction of the pupils, irritability, low blood pressure, sleepiness, slow heartbeat, sluggishness
Wytensin Alcohol interaction
[Moderate]
Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation.
Coadministration with antihypertensives and other hypotensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis.
Caution and close monitoring for development of hypotension is advised during coadministration of these agents.
Some authorities recommend avoiding alcohol in patients receiving vasodilating antihypertensive drugs.
Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia.
Wytensin Drug Interaction
Moderate: aripiprazole, aripiprazole, diphenhydramine, diphenhydramineUnknown: amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, ubiquinone, ubiquinone, torsemide, torsemide, bisacodyl, bisacodyl, multivitamin, multivitamin, cyanocobalamin, cyanocobalamin, cholecalciferol, cholecalciferol
Wytensin Disease Interaction
Moderate: bradyarrhythmia, depression, hypotension, liver disease, renal dysfunction
Elimination Route
Approximately 75% absorbed from gastrointestinal tract
Half Life
6 hours.
Innovators Monograph
You find simplified version here Wytensin
