Kepivance

Kepivance Uses, Dosage, Side Effects, Food Interaction and all others data.

Kepivance is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli.

Kepivance was granted FDA approval on 15 December 2004.

Used in the prevention or treatment of oral mucoscitis (mouth ulcers arising from chemotherapy), Kepivance binds to the human keratinocyte growth factor (KGF) receptor on buccal cell surfaces. Kepivance acts as both a cell growth and survival factor by stimulating epithelial cell proliferation, differentiation, and migration around the tongue and mouth. The KGF receptor is found on many tissues particularly around the tongue, esophagus, salivary gland and other gastro-intestinal tract organs.

Kepivance
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	Kepivance
Availability	Prescription only
Generic	Palifermin
Palifermin Other Names	24-163 fibroblast growth factor 7 (human), Palifermin, Palifermina
Related Drugs	chlorhexidine topical, Peridex, sodium hyaluronate topical, Biotene Mouthwash, XyliMelts
Weight	6.25mg,
Type	Intravenous powder for injection
Formula	C₇₂₁H₁₁₄₂N₂₀₂O₂₀₄S₉
Weight	16192.7 Da
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	United States, France, Italy, Netherlands, Portugal, Spain,
Last Updated:	September 19, 2023 at 7:00 am

Uses

Kepivance is a form of recombinant human keratinocyte growth factor used to prevent and treat oral mucositis following radiation or chemotherapy.

For treatment of oral mucositis associated with chemotherapy and radiation therapy.

Kepivance is also used to associated treatment for these conditions: Oral Mucositis

How Kepivance works

Kepivance has been shown to protect oral and intestinal epithelia from the effects of radiation and chemotherapy, though the exact mechanism is not well understood. As a recombinant keratinocyte growth factor (KGF), palifermin may promote cell proliferation, reducing the severity of oral mucositis in patients in the relevant treatment groups. Agonism of fibroblast growth factor 2 may be predominantly responsible for this effect. The endogenous form if palifermin is expressed in the kidney of rats.