Idarubicine Uses, Dosage, Side Effects, Food Interaction and all others data.

An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity.

Idarubicine is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Idarubicine may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Idarubicine possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Trade Name Idarubicine
Availability Prescription only
Generic Idarubicin
Idarubicin Other Names 4-Demethoxydaunorubicin, Idarubicin, Idarubicina, Idarubicine, Idarubicinum
Related Drugs Venclexta, prednisone, methotrexate, dexamethasone, triamcinolone, Decadron, Keytruda, hydroxyurea, pembrolizumab, vincristine
Formula C26H27NO9
Weight Average: 497.4939
Monoisotopic: 497.168581467
Protein binding


Groups Approved
Therapeutic Class
Available Country
Last Updated: September 19, 2023 at 7:00 am


Idarubicine is an anthracycline antineoplastic agent used to treat acute myeloid leukemia (AML) in adults.

For the treatment of acute myeloid leukemia (AML) in adults. This includes French-American-British (FAB) classifications M1 through M7.

Idarubicine is also used to associated treatment for these conditions: Acute Myeloid Leukemia (AML)

How Idarubicine works

Idarubicine has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Idarubicine forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

Food Interaction

No interactions found.

Half Life

22 hours

Elimination Route

The drug is eliminated predominately by biliary and to a lesser extent by renal excretion, mostly in the form of idarubicinol.

Innovators Monograph

You find simplified version here Idarubicine

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