Podophyllotoxin

Podophyllotoxin Uses, Dosage, Side Effects, Food Interaction and all others data.

Podophyllotoxin has an antimitotic action and is used mainly as a topical treatment for anogenital warts.

Podophyllotoxin, also called podophyllotoxin, is a purer and more stable form of podophyllin in which only the biologically active portion of the compound is present. Podophyllotoxin is used to remove certain types of warts on the outside skin of the genital areas.

Trade Name Podophyllotoxin
Availability Prescription only
Generic Podofilox
Podofilox Other Names Podofilox, Podophyllotoxin
Related Drugs imiquimod topical, Aldara, interferon alfa-2b, Condylox, Intron A, Veregen
Type
Formula C22H22O8
Weight Average: 414.4053
Monoisotopic: 414.13146768
Groups Approved
Therapeutic Class Anti neoplastic preparations
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Podophyllotoxin
Podophyllotoxin

Uses

For the removal of external genital warts located on the penis and vulva

Podophyllotoxin (PPT), also known as podofilox, is a medical cream that is used to treat genital warts and molluscum contagiosum. It is not recommended in HPV infections without external warts. It can be applied either by a healthcare provider or the person themselves.

Podophyllotoxin is also used to associated treatment for these conditions: External Genital Warts, Perianal Warts

How Podophyllotoxin works

The exact mechanism of action is not well understood. It does appear, however, that it and its derivatives may bind and inhibit topoisomerase II during the late S and early G2 stage. The drug may bind and stabilize the temporary break caused by the enzyme. This disrupts the reparation of the break through which the double-stranded DNA passes, and consequently stops DNA unwinding and replication

Dosage

Podophyllotoxin dosage

Apply twice daily, morning and evening (every 12 hours) for three consecutive days followed by four days without treatment. The use of 0.5% Podophyllotoxin Topical Solution is twice a day for three days constitutes a treatment cycle. Treatment cycles should be repeated up to four times until there is no visible wart tissue.

Side Effects

Irritating to the eyes and mucous membranes; GI disturbances; thrombocytopenia, leucopenia; renal failure; hepatotoxicity; CNS effects; EEG changes; peripheral and autonomic neuropathies; local reactions

Precaution

Avoid excessive application. Avoid contact with eyes and inflamed skin. Not to be used on cervical or urethral warts.

Food Interaction

No interactions found.

Elimination Route

Topical application of 0.05 mL of 0.5% podofilox solution to external genitalia did not result in detectable serum levels. Applications of 0.1 to 1.5 mL resulted in peak serum levels of 1 to 17 ng/mL one to two hours after application.

Half Life

1.0 to 4.5 hours.

Pregnancy & Breastfeeding use

Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Contraindication

Hypersensitivity; pregnancy; lactation; child.

Innovators Monograph

You find simplified version here Podophyllotoxin

Podophyllotoxin contains Podofilox see full prescribing information from innovator Podophyllotoxin Monograph, Podophyllotoxin MSDS, Podophyllotoxin FDA label

*** Taking medicines without doctor's advice can cause long-term problems.
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