Diazoxidum

Diazoxidum Uses, Dosage, Side Effects, Food Interaction and all others data.

A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.

Diazoxidum is a potassium channel activator. Its mechanism of action revolves around enhancing cell membrane permeability to potassium ions. This action consequently elicits the relaxation of local smooth muscles. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.

Trade Name Diazoxidum
Availability Prescription only
Generic Diazoxide
Diazoxide Other Names Diazossido, Diazoxide, Diazoxido, Diazoxidum
Related Drugs hydralazine, nifedipine, captopril, enalapril, labetalol, glucagon, methyldopa, Baqsimi, Gvoke, GlucaGen
Type
Formula C8H7ClN2O2S
Weight Average: 230.671
Monoisotopic: 229.991675875
Protein binding

Very high (more than 90%) to serum proteins.

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Diazoxidum
Diazoxidum

Uses

Diazoxidum is a non diuretic benzothiadiazine indicated for the management of hypoglycemia in patients who produce an excess of insulin caused by a variety of conditions.

Used parentally to treat hypertensive emergencies. Also used to treat hypoglycemia secondary to insulinoma.

Diazoxidum is also used to associated treatment for these conditions: Hyperinsulinemic Hypoglycemia

How Diazoxidum works

Diazoxidum inhibits insulin release from the pancreas, by opening potassium channels in the beta cell membrane. Diazoxidum is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. It also exhibits hypotensive activity by reducing arteriolar smooth muscle and vascular resistance.

Toxicity

Oral LD50 in rat and mouse: 980 mg/kg and 444 mg/kg, respectively.

Food Interaction

No interactions found.

Elimination Route

Readily absorbed following oral administration.

Half Life

28 ±8.3 hours in normal adults.

Elimination Route

Proglycem is extensively bound (more than 90%) to serum proteins, and is excreted in the kidneys.

Innovators Monograph

You find simplified version here Diazoxidum

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000002
http://classyfire.wishartlab.com/tax_nodes/C0000224
http://classyfire.wishartlab.com/tax_nodes/C0000308
http://classyfire.wishartlab.com/tax_nodes/C0004292
http://classyfire.wishartlab.com/tax_nodes/C0003886
http://classyfire.wishartlab.com/tax_nodes/C0002448
http://classyfire.wishartlab.com/tax_nodes/C0001030
http://classyfire.wishartlab.com/tax_nodes/C0000270
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0000007
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0001516
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:4495
http://www.hmdb.ca/metabolites/HMDB0015251
http://www.genome.jp/dbget-bin/www_bget?drug:D00294
http://www.genome.jp/dbget-bin/www_bget?cpd:C06949
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3019
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508027
https://www.chemspider.com/Chemical-Structure.2911.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86248
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=3327
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=4495
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL181
https://zinc.docking.org/substances/ZINC000003872277
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000956
http://www.pharmgkb.org/drug/PA449285
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2409
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/20J
https://www.drugs.com/cdi/diazoxide-suspension.html
https://en.wikipedia.org/wiki/Diazoxide
*** Taking medicines without doctor's advice can cause long-term problems.
Share