BCR-ABL1 Genetic Test

What is a BCR-ABL1 Genetic Test?

A BCR-ABL1 genetic test is a laboratory test that can detect gene rearrangement in the BCR-ABL1 gene in individuals with Philadelphia chromosome-positive chronic myeloid leukemia (CML). The BCR-ABL1 gene mutation is a type of abnormal fusion protein called BCR-ABL1, which results from an abnormality in chromosome 22.

Why the BCR-ABL1 Genetic Test is Performed?

The BCR-ABL1 genetic test is performed to determine whether a person has a gene abnormality in the BCR-ABL1 gene. This test is most often used to monitor response to treatment in individuals with Philadelphia chromosome-positive CML.

Preparing for a BCR-ABL1 Genetic Test?

No specific preparations are needed for this test.

Types of BCR-ABL1 Genetic Tests?

The BCR-ABL1 genetic test can be performed using several methods, including polymerase chain reaction (PCR) and fluorescence in situ hybridization (FISH).

Risks of BCR-ABL1 Genetic Test?

There are little to no risks associated with the BCR-ABL1 genetic test, as it is a painless and non-invasive procedure.

When is BCR-ABL1 Genetic Test Done?

The BCR-ABL1 genetic test is typically done when an individual has been diagnosed with Philadelphia chromosome-positive CML. It may also be recommended for those who are being treated with medications that target the BCR-ABL1 gene, such as imatinib or dasatinib, in order to monitor response to treatment.