Recurrent Glioblastoma Multiforme


Understanding Recurrent Glioblastoma Multiforme

Glioblastoma multiforme (GBM) is a very aggressive type of brain tumor that is difficult to treat. It is the most common and most aggressive brain tumor in adults. A recurrent GBM is a tumor that has come back after its initial treatment. It often comes back with a higher grade, which makes it even more aggressive. Recurrent GBM can be more difficult to treat than the original tumor because it is often resistant to chemotherapy and radiation.

Recurrent GBM is caused by a mutation in the DNA of the tumor cells, which allows it to grow more rapidly than the original tumor. It is more likely to happen if the original GBM was not treated adequately or if it was not completely removed.

Symptoms of Recurrent Glioblastoma Multiforme

The symptoms of recurrent GBM can vary depending on where the tumor is located. Some common symptoms include:

  • Headaches
  • Vomiting
  • Seizures
  • Personality changes
  • Loss of coordination
  • Numbness or weakness in the limbs
  • Memory problems

Diagnosis and Treatment of Recurrent Glioblastoma Multiforme

Diagnosis of recurrent GBM usually begins with a physical exam and neurological exam. A doctor may order an MRI or CT scan to look for any evidence of a tumor. If the tumor is found, a biopsy may be done to confirm the diagnosis.

The treatment of recurrent GBM depends on the size and location of the tumor and the patient’s overall health. It usually involves a combination of surgery, radiation, and chemotherapy. Other treatments, such as stem cell transplantation and immunotherapy, may also be recommended.

Prognosis for recurrent GBM is generally poor since the tumor is so aggressive. Life expectancy typically ranges from six to twelve months. However, some patients may live longer with aggressive treatment.