NTRK3 Fusion Positive

What is NTRK3 Fusion Positive?

NTRK3 fusion-positive tumors are rare cancers that occur when two parts of the NTRK3 gene become abnormally joined together. This fusion creates an abnormal protein that signals cells to grow uncontrollably, leading to highly aggressive tumor growth.

NTRK3 fusion-positive tumors can occur anywhere in the body and can be found in adults and children. These rare cancers have been reported in genetic testing in a range of different tumor types, including thyroid, lung, and skin cancer.

Symptoms of NTRK3 Fusion Positive

The symptoms of NTRK3 fusion-positive tumors depend on the type and location of the tumor. Generally, symptoms include:

  • Chronic pain
  • Weight loss
  • Fatigue
  • Lumps in the neck or throat
  • Shortness of breath
  • Coughing up blood

Diagnosis of NTRK3 Fusion Positive

The diagnosis of NTRK3 fusion-positive tumors is made through genetic testing. Your doctor may order tests to look for specific mutations, including DNA sequencing and reverse transcriptase polymerase chain reaction (RT-PCR).

Your doctor may also order additional imaging tests to get more information about the tumor, such as an MRI, CT scan, or PET scan.

Treatment of NTRK3 Fusion Positive

The treatment of NTRK3 fusion-positive tumors depends on the type and location of the tumor, as well as the patient’s overall health. Treatment may include:

  • Surgery to remove the tumor
  • Chemotherapy to shrink the tumor before surgery
  • Radiation therapy to shrink the tumor
  • Targeted therapy to block the action of the tumor’s abnormal protein

In some cases, targeted therapy may be used as a primary treatment option. Targeted therapies target specific parts of cancer cells that help them grow. These therapies may help slow or stop tumor growth.