Zinplava

Zinplava Uses, Dosage, Side Effects, Food Interaction and all others data.

Zinplava is a human monoclonal antibody that binds to Clostridium difficile toxin B and neutralizes its effects. Used to reduce the recurrence of Clostridium difficle infection in adults receiving antibiotic therapy to treat C. difficile infection and high risk of recurrence.

Zinplava binds to C.difficile toxin B, a virulence factor common to practically all C.difficile, which prevents the bacteria from infecting host cells. Zinplava binds two epitopes of toxin B, via two Fab regions, which partially blocks the carbohydrate binding pockets of the toxin resulting in the prevention of toxin B from binding to host cells.

Zinplava
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	Zinplava
Availability	Prescription only
Generic	Bezlotoxumab
Bezlotoxumab Other Names	Bezlotoxumab
Related Drugs	Zinplava
Weight	25mg/ml,
Type	Infusion, Intravenous Solution
Protein binding	Binds to C.difficile virulence factor toxin B which prevents its action on host cells.
Groups	Approved, Investigational
Therapeutic Class
Manufacturer	Merck Sharp & Dohme (UK) Limited
Available Country	Australia, United Kingdom, United States,
Last Updated:	September 19, 2023 at 7:00 am

Uses

Zinplava is a monoclonal antibody used to reduce the recurrence of Clostridium difficile infections.

Prevents recurrence of Clostridium difficile infection in people 18 years or older who are either currently receiving treatment for C. difficile infection or have a high risk of recurrence.

Zinplava is also used to associated treatment for these conditions: Clostridium difficile infection recurrence

How Zinplava works

A single molecule of bezlotoxumab neutralizes Toxin B by binding its two Fab regions to two epitopes within the N-terminal half of the Toxin B CROP domain, partially blocking the carbohydrate binding pockets of the toxin and preventing toxin binding to host cells.