Bezlotoxumab

Bezlotoxumab Uses, Dosage, Side Effects, Food Interaction and all others data.

Bezlotoxumab is a human monoclonal antibody that binds to Clostridium difficile toxin B and neutralizes its effects. Used to reduce the recurrence of Clostridium difficle infection in adults receiving antibiotic therapy to treat C. difficile infection and high risk of recurrence.

Bezlotoxumab binds to C.difficile toxin B, a virulence factor common to practically all C.difficile, which prevents the bacteria from infecting host cells. Bezlotoxumab binds two epitopes of toxin B, via two Fab regions, which partially blocks the carbohydrate binding pockets of the toxin resulting in the prevention of toxin B from binding to host cells.

Bezlotoxumab
Uses
Dosage
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Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
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Interaction With other Medicine
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Trade Name	Bezlotoxumab
Availability	Prescription only
Generic	Bezlotoxumab
Bezlotoxumab Other Names	Bezlotoxumab
Related Drugs	Zinplava
Weight	25mg/ml,
Type	Intravenous Solution, Intravenous
Protein binding	Binds to C.difficile virulence factor toxin B which prevents its action on host cells.
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Bezlotoxumab is a monoclonal antibody used to reduce the recurrence of Clostridium difficile infections.

Prevents recurrence of Clostridium difficile infection in people 18 years or older who are either currently receiving treatment for C. difficile infection or have a high risk of recurrence.

Bezlotoxumab is also used to associated treatment for these conditions: Clostridium difficile infection recurrence

How Bezlotoxumab works

A single molecule of bezlotoxumab neutralizes Toxin B by binding its two Fab regions to two epitopes within the N-terminal half of the Toxin B CROP domain, partially blocking the carbohydrate binding pockets of the toxin and preventing toxin binding to host cells.