Vardenafil Chanelle

Vardenafil Chanelle Uses, Dosage, Side Effects, Food Interaction and all others data.

Does not directly cause penile erections, but affects the response to sexual stimulation. The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation and inflow of blood to the corpus cavernosum. Vardenafil Chanelle enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE-5), which is responsible for degradation of cGMP in the corpus cavernosum; when sexual stimulation causes local release of NO, inhibition of PDE-5 by vardenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum; at recommended doses, it has no effect in the absence of sexual stimulation.

Vardenafil Chanelle is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Vardenafil Chanelle is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with vardenafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, vardenafil should not cause an erection.

Trade Name Vardenafil Chanelle
Availability Prescription only
Generic Vardenafil
Vardenafil Other Names Vardénafil, Vardenafil, Vardenafilo, Vardenafilum
Related Drugs sildenafil, tadalafil, Viagra, Cialis, alprostadil, Levitra
Formula C23H32N6O4S
Weight Average: 488.603
Monoisotopic: 488.220574232
Protein binding


Groups Approved
Therapeutic Class Drugs for Erectile Dysfunction
Manufacturer Ridge Pharma Ltd
Available Country United Kingdom
Last Updated: September 19, 2023 at 7:00 am
Vardenafil Chanelle
Vardenafil Chanelle


Vardenafil Chanelle is used to treat erectile dysfunction (ED).

Vardenafil Chanelle is also used to associated treatment for these conditions: Erectile Dysfunction

How Vardenafil Chanelle works

Vardenafil Chanelle inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by vardenafil enhances erectile function by increasing the amount of cGMP.


Vardenafil Chanelle dosage

Initial dose: 10 mg orally once a day, as needed, approximately 60 minutes before sexual activity. Increase to 20 mg or decrease to 5 mg based on efficacy and tolerability.

Maximum dose: 20 mg once a day

Usual Geriatric Dose for Erectile Dysfunction (65 years or older): 5 mg orally once a day, as needed, approximately 60 minutes before sexual activity

Patients on stable alpha blocker therapy: 5 mg orally once a day

Side Effects

Dyspepsia, vomiting, headache, flushing, dizziness, visual disturbances, colour vision changes, raised intra-ocular pressure, nasal congestion, hypersensitivity reactions, nausea, photosensitivity reactions, hypotension, hypertension, priapism, palpitations, myalgia, increased creatinine kinase, sudden decrease or loss of hearing, tinnitus.


Symptoms of overdose include vision changes and back and muscle pain.


Safety and efficacy have not been established in patients younger than 18 years. This drug is not indicated for use in pediatric patients.


Increased risk of hypotension with α-blockers. Increased risk of priapism with alprostadil. Increased serum levels of vardenafil when used with erythromycin.

Food Interaction

  • Avoid grapefruit products. Vardenafil Chanelle is metabolized by CYP3A4, and grapefruit products are CYP3A4 inhibitors; therefore, coadministration may increase serum levels of vardenafil and result in increased hypotension. .
  • Take with or without food.

[Moderate] MONITOR: Grapefruit juice may increase the plasma concentrations of orally administered drugs that are substrates of the CYP450 3A4 isoenzyme.

The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit.

Because grapefruit juice inhibits primarily intestinal rather than hepatic CYP450 3A4, the magnitude of interaction is greatest for those drugs that undergo significant presystemic metabolism by CYP450 3A4 (i.e., drugs with low oral bioavailability).

In general, the effect of grapefruit juice is concentration-, dose- and preparation-dependent, and can vary widely among brands.

Certain preparations of grapefruit juice (e.g., high dose, double strength) have sometimes demonstrated potent inhibition of CYP450 3A4, while other preparations (e.g., low dose, single strength) have typically demonstrated moderate inhibition.

Pharmacokinetic interactions involving grapefruit juice are also subject to a high degree of interpatient variability, thus the extent to which a given patient may be affected is difficult to predict.

MANAGEMENT: Patients who regularly consume grapefruit or grapefruit juice should be monitored for adverse effects and altered plasma concentrations of drugs that undergo significant presystemic metabolism by CYP450 3A4.

Grapefruit and grapefruit juice should be avoided if an interaction is suspected.

Orange juice is not expected to interact with these drugs.

Vardenafil Chanelle Alcohol interaction


Additive hypotensive effects may occur when phosphodiesterase-5 (PDE5) inhibitors are used with alcohol, as both are mild systemic vasodilators.

In clinical pharmacology studies, more subjects administered alcohol at a dose of 0.7 g/kg (equivalent to approximately 6 ounces of 80-proof vodka in an 80-kg male; consumed within 10 minutes in study subjects, providing blood alcohol levels of 0.08%) in combination with tadalafil 10 or 20 mg single doses had clinically significant decreases in blood pressure than with alcohol alone.

There were reports of postural dizziness, and orthostatic hypotension was observed in some.

When tadalafil 20 mg was administered with alcohol at a lower dose of 0.6 g/kg (equivalent to approximately 4 ounces of 80-proof vodka in an 80-kg male), orthostatic hypotension was not observed, dizziness occurred with similar frequency relative to alcohol alone, and the hypotensive effects of alcohol were not potentiated.

Neither tadalafil nor alcohol affected the plasma concentrations of the other.

Administration of avanafil 200 mg with alcohol at a dose of 0.5 g/kg (equivalent to approximately 3 ounces of 80-proof vodka in a 70-kg male; consumed within 15 minutes in study subjects, providing blood alcohol levels of 0.057%) resulted in additional maximum supine systolic/diastolic blood pressure decreases of 3.5/4.5 mm Hg and additional maximum pulse rate increase of 9.3 bpm compared to alcohol alone, but did not cause orthostatic hypotension or dizziness.

The plasma concentrations of alcohol were not affected.

Sildenafil 50 mg and vardenafil 20 mg reportedly did not potentiate the hypotensive effect of alcohol in healthy volunteers with mean maximum blood alcohol levels of 0.08% and in healthy volunteers administered alcohol at a dose of 0.5 g/kg, respectively.

Alcohol and vardenafil plasma levels were not altered when dosed simultaneously.

Patients taking PDE5 inhibitors should avoid consuming large amounts of alcohol, which may increase the potential for orthostatic signs and symptoms including increase in heart rate, decrease in standing blood pressure, dizziness, and headache.

Volume of Distribution

  • 208 L

Elimination Route

Vardenafil Chanelle is rapidly absorbed with absolute bioavailability of approximately 15%.

Half Life

4-5 hours


  • 56 L/h

Elimination Route

After oral administration, vardenafil is excreted as metabolites predominantly in the feces (approximately 91-95% of administered oral dose) and to a lesser extent in the urine (approximately 2-6% of administered oral dose).

Pregnancy & Breastfeeding use

Pregnancy Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).


Known prolongation of QT interval (congenital or acquired); men for whom sexual intercourse is inadvisable due to CV risk factors; hypotension (systolic 170 mm Hg or diastolic >110 mm Hg); recent stroke or MI (within last 6 mth); unstable angina; severe heart failure; end-stage renal disease requiring dialysis; severe hepatic impairment; known degenerative retinal disorders e.g. retinitis pigmentosa. Women, child.

Special Warning

Patients stabilised on α-blocker therapy: max daily dose 5 mg and not to be taken within 6 hr of the α-blocker (except tamsulosin). Patients on erythromycin: Max: 5 mg daily.Renal Impairment: Haemodialysis: Avoid.Hepatic Impairment:

  • Child Pugh A-B (mild to moderate) impairment: Initiate with 5 mg.
  • Max dose in moderate impairment: 10 mg.
  • Child-Pugh C (severe impairment): No studies done.

Storage Condition

Store between 15-30° C.

Innovators Monograph

You find simplified version here Vardenafil Chanelle

Vardenafil Chanelle contains Vardenafil see full prescribing information from innovator Vardenafil Chanelle Monograph, Vardenafil Chanelle MSDS, Vardenafil Chanelle FDA label


What is Vardenafil Chanelle use for?

Vardenafil Chanelle is an oral therapy that use for the improvement of erectile function in men with erectile dysfunction. In the natural setting, i.e., with sexual stimulation, it restores impaired erectile function by increasing blood flow to the penis.

How long does Vardenafil Chanelle take to work?

Vardenafil Chanelle is taken 25 to 60 minutes before sex. The effect lasts for up to 5 hours.

What are the side effects of Vardenafil Chanelle?

Vardenafil Chanelle may cause side effects include.

  • headache.
  • upset stomach.
  • heartburn.
  • flushing.
  • stuffy or runny nose.
  • flu-like symptoms.

Can I take Vardenafil Chanelle daily?

Not more than 20 mg once per day. Adults up to 65 years—10 mg as a single dose, no more than once per day.

Can I take Vardenafil Chanelle with alcohol?

It is likely safe to take Vardenafil Chanelle with alcohol if you are drinking in moderation and have consulted with your healthcare provider. Excessive alcohol consumption can increase the risk of serious side effects and can worsen sexual dysfunction.

Can I take Vardenafil Chanelle for a long time?

Is not for continuous daily use.Take Vardenafil Chanelle exactly as your doctor tells you to.

How safe is Vardenafil Chanelle?

Vardenafil Chanelle is generally safe, and serious side effects are uncommon. But in rare cases, Vardenafil Chanelle can contribute to conditions that require a doctor's attention.

Is there any food or drink I need to avoid when taking Vardenafil Chanelle?

While a high-fat meal may alter slightly and delay the absorption up to 1 hour, a moderate-fat meal has no clinically relevant effect on Vardenafil Chanelle pharmacokinetics.

Will Vardenafil Chanelle affect my fertility?

We showed the efficacy of Vardenafil Chanelle in the treatment of ED and, on a large series of infertile patients, the positive effect on sperm motility after a single-dose administration. It also showed that after 15 days of treatment on alternate days is also achieved an improvement in sperm concentration.

How long does Vardenafil Chanelle stay in my system?

The effects of Vardenafil Chanelle last for about 4 hours.Vardenafil Chanelle is taken only when needed, about 60 minutes before sexual activity. The medicine can help achieve an erection when sexual stimulation occurs.

Is Vardenafil Chanelle dangerous?

Vardenafil Chanelle can cause a serious drop in your blood pressure when used with nitrates, which can lead to dizziness, fainting, and rarely heart attack or stroke.

Is Vardenafil Chanelle bad for your heart?

Vardenafil Chanelle increases heart rate and also exaggerates blood pressure lowering effects of nitrates. In patients with chest pain (angina), Levitra can cause chest pain by increasing heart rate and lowering blood pressure.

Does Vardenafil Chanelle cause headache?

Headaches are a common side effect of erectile dysfunction medications such as Vardenafil Chanelle with about 25 percent of men prescribed reporting some level of headache after using the medication.

Who should not take Vardenafil Chanelle?

Vardenafil Chanelle is not approved for men younger than 18 years old. Do not take Vardenafil Chanelle if you are also using a nitrate drug for chest pain or heart problems.

When is the best time to take Vardenafil Chanelle?

best time to take Vardenafil Chanelle about 60 minutes before sexual activity.It usually should not be taken more often than once every 24 hours.

*** Taking medicines without doctor's advice can cause long-term problems.