Trimetaphan

Trimetaphan Uses, Dosage, Side Effects, Food Interaction and all others data.

A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery.

Trimetaphan is indicated for production of controlled hypotension during surgery to reduce bleeding into the surgical field and also for rapid reduction of blood pressure in the treatment of hypertensive emergencies, especially in patients with acute dissecting aneurysm, and in the emergency treatment of pulmonary edema in patients with pulmonary hypertension associated with systemic hypertension.

Trade Name Trimetaphan
Generic Trimethaphan
Trimethaphan Other Names Thimethaphan, Trimetaphan, Trimetaphanum
Type
Formula C22H25N2OS
Weight Average: 365.512
Monoisotopic: 365.168759122
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Trimetaphan
Trimetaphan

Uses

For the controlled reduction of blood pressure during surgery and in the treatment of hypertensive emergencies.

How Trimetaphan works

Trimetaphan is a ganglionic blocking agent prevents stimulation of postsynaptic receptors by competing with acetylcholine for these receptor sites. Additional effects may include direct peripheral vasodilation and release of histamine. Trimetaphan's hypotensive effect is due to reduction in sympathetic tone and vasodilation, and is primarily postural.

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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