Tisomycin

Tisomycin Uses, Dosage, Side Effects, Food Interaction and all others data.

Antibiotic substance produced by Streptomyces garyphalus.

Tisomycin, a broad-spectrum antibiotic, may be bactericidal or bacteriostatic, depending on its concentration at the site of infection and the susceptibility of the organism. Tisomycin works by blocking the formation of these peptidoglycans. By doing this the walls of the bacteria become weak and it results in the death of the bacteria

Trade Name Tisomycin
Availability Prescription only
Generic Cycloserine
Cycloserine Other Names alpha-Cycloserine, Cicloserina, cyclo-D-Serine, Cycloserine, Cyclosérine, Cycloserinum, D-Cycloserine, Orientomycin
Related Drugs prednisone, ciprofloxacin, levofloxacin, Levaquin, rifampin, Deltasone, Sterapred, Prednicot
Type
Formula C3H6N2O2
Weight Average: 102.0919
Monoisotopic: 102.042927446
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Tisomycin
Tisomycin

Uses

Tisomycin is a broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI).

Used in combination with up to 5 other drugs as a treatment for Mycobacterium avium complex (MAC) and is also used to treat tuberculosis (TB).

Tisomycin is also used to associated treatment for these conditions: Refractory Tuberculosis, Refractory Urinary Tract Infection

How Tisomycin works

Tisomycin is an analog of the amino acid D-alanine. It interferes with an early step in bacterial cell wall synthesis in the cytoplasm by competitive inhibition of two enzymes, L-alanine racemase, which forms D-alanine from L-alanine, and D-alanylalanine synthetase, which incorporates D-alanine into the pentapeptide necessary for peptidoglycan formation and bacterial cell wall synthesis.

Toxicity

Oral LD50 in mouse is 5290 mg/kg, and in rat is over 5000 mg/kg. Symptoms of a cycloserine overdose include drowsiness, confusion, headache, dizziness, irritability, numbness and tingling, difficulty speaking, paralysis, abnormal behavior, seizures, and unconsciousness.

Food Interaction

  • Do not take with or immediately after a high-fat meal. High-fat meals may reduce the rate of absorption; however, the impact on the extent of absorption is unknown.

[Major] GENERALLY AVOID: Coadministration with alcohol may potentiate some of the central nervous system adverse effects of cycloserine and its prodrug, terizidone.

These effects may include dizziness, drowsiness, depression, anxiety, psychoses, memory impairment, confusion, and convulsions.

MANAGEMENT: Patients should be advised to avoid the consumption of alcohol during treatment with cycloserine or terizidone.

The use of these medications is contraindicated in patients with chronic alcohol consumption or alcoholism.

MONITOR CLOSELY: Coadministration with caffeine may potentiate some of the central nervous system adverse effects of cycloserine and its prodrug, terizidone.

These effects may include insomnia, excitability, irritability, anxiety, tremor, psychoses, and convulsions.

MANAGEMENT: Caution is advised when cycloserine or terizidone is used with caffeine.

Consumption of certain beverages or stimulants with very high caffeine levels should be avoided as a precautionary measure.

Tisomycin Disease Interaction

Major: colitis, CNS toxicity, renal dysfunction

Elimination Route

Rapidly and almost completely absorbed (70 to 90%) from the gastrointestinal tract following oral administration.

Half Life

Half-life in patients with normal renal function is 10 hours, and is prolonged in patients with impaired renal function.

Innovators Monograph

You find simplified version here Tisomycin

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000002
http://classyfire.wishartlab.com/tax_nodes/C0002490
http://classyfire.wishartlab.com/tax_nodes/C0002211
http://classyfire.wishartlab.com/tax_nodes/C0002211
http://classyfire.wishartlab.com/tax_nodes/C0004140
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000323
http://classyfire.wishartlab.com/tax_nodes/C0000469
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:40009
http://www.genome.jp/dbget-bin/www_bget?cpd:C08057
http://www.lipidmaps.org/data/LMSDRecord.php?LMID=LMPK14000007
http://www.hmdb.ca/metabolites/HMDB0014405
http://www.genome.jp/dbget-bin/www_bget?cpd:C08057
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6234
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506865
https://www.chemspider.com/Chemical-Structure.5998.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038178
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=3007
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=40009
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL771
https://zinc.docking.org/substances/ZINC000034676245
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP001468
http://www.pharmgkb.org/drug/PA164764600
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/4AX
https://www.drugs.com/cdi/cycloserine.html
https://en.wikipedia.org/wiki/Cycloserine
*** Taking medicines without doctor's advice can cause long-term problems.
Share