Thiethylperazine

Thiethylperazine Uses, Dosage, Side Effects, Food Interaction and all others data.

A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)

Thiethylperazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, Thiethylperazine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors.

Trade Name Thiethylperazine
Availability Discontinued
Generic Thiethylperazine
Thiethylperazine Other Names Norzine, Thiethylperazin, Thiéthylpérazine, Thiethylperazine, Thiethylperazinum, Tietilperazina
Related Drugs hydroxyzine, lorazepam, ondansetron, Zofran, meclizine, promethazine
Type
Formula C22H29N3S2
Weight Average: 399.616
Monoisotopic: 399.180289323
Protein binding

60%

Groups Approved, Withdrawn
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Thiethylperazine
Thiethylperazine

Uses

Thiethylperazine is a drug used for the treatment of nausea and vomiting.

For the treatment or relief of nausea and vomiting.

Thiethylperazine is also used to associated treatment for these conditions: Nausea and vomiting

How Thiethylperazine works

Thiethylperazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Thiethylperazine's antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors. This may explain the lack of extrapyramidal effects. Thiethylperazine does not appear to block dopamine within the tubero-infundibular tract, explaining the lower incidence of hyperprolactinemia than with typical antipsychotic agents or risperidone. Antagonism at muscarinic receptors, H1-receptors, and alpha(1)-receptors also occurs with thiethylperazine.

Toxicity

Manifestations of acute overdosage of TORECAN (thiethylperazine) can be expected to reflect the CNS effects of the drug and include extrapyramidal symptoms (E.P.S), confusion and convulsions with reduced or absent reflexes, respiratory depression and hypotension.

Thiethylperazine Alcohol interaction

[Moderate] GENERALLY AVOID:

Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.

Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines.

The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.



Patients should be advised to avoid alcohol during phenothiazine therapy.

Elimination Route

Thiethylperazine is eliminated in the urine.

Innovators Monograph

You find simplified version here Thiethylperazine

*** Taking medicines without doctor's advice can cause long-term problems.
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